Bowel preparation with split-dose polyethylene glycol before colonoscopy: a meta-analysis of randomized controlled trials
| Autor: | Abhishek Choudhary, Todd W. Kilgore, Nicholas M. Szary, Matthew L. Bechtold, John B. Marshall, Jamie B. Yust, Srinivas R. Puli, Abdillahi Abdi Abdinoor, Samuel W. Schowengerdt, Michelle Matteson |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Nausea Ottawa Bowel Preparation Scale Colonoscopy Polyethylene glycol Gastroenterology Polyethylene Glycols law.invention Surface-Active Agents chemistry.chemical_compound Randomized controlled trial law Internal medicine PEG ratio medicine Humans Radiology Nuclear Medicine and imaging Randomized Controlled Trials as Topic medicine.diagnostic_test Cathartics business.industry Odds ratio Surgery chemistry Meta-analysis Patient Compliance medicine.symptom business |
| Zdroj: | Gastrointestinal Endoscopy. 73:1240-1245 |
| ISSN: | 0016-5107 |
| DOI: | 10.1016/j.gie.2011.02.007 |
| Popis: | Background Polyethylene glycol (PEG) is a commonly used bowel preparation for colonoscopy. Unfortunately, the standard large-volume solution may reduce patient compliance. Split-dosing of PEG has been studied in various randomized, controlled trials (RCTs). However, results have been conflicting. Objective We conducted a meta-analysis to assess the role of split-dose PEG versus full-dose PEG for bowel preparation before colonoscopy. Design Multiple databases were searched (January 2011). RCTs on adults comparing full-dose and split-dose of PEG for bowel preparation before colonoscopy were included and analyzed by calculating pooled estimates of quality of bowel preparation, preparation compliance, willingness to repeat the same preparation, and side effects by using odds ratio (OR) by fixed and random-effects models. Setting Literature search. Patients Per RCTs. Main Outcome Measurements Satisfactory bowel preparation, willingness to repeat same bowel preparation, patient compliance, and side effects. Results Five trials met inclusion criteria (N = 1232). Split-dose PEG significantly increased the number of satisfactory bowel preparations (OR 3.70; 95% CI, 2.79-4.91; P P = .03) compared with full-dose PEG. Split-dose PEG also significantly decreased the number of preparation discontinuations (OR 0.53; 95% CI, 0.28-0.98; P = .04) and nausea (OR 0.55; 95% CI, 0.38-0.79; P Limitations Limited number of studies. Conclusions The use of a split-dose PEG for bowel preparation before colonoscopy significantly improved the number of satisfactory bowel preparations, increased patient compliance, and decreased nausea compared with the full-dose PEG. |
| Databáze: | OpenAIRE |
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