Autoimmune thyroiditis and exposure to iodine 131 in the Ukrainian cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: results from the first screening cycle (1998-2000)
| Autor: | Victor Shpak, Mykola Tronko, Daniel J. Fink, Valery P. Tereshchenko, Galyna Terekhova, Geoffrey R. Howe, Ovsiy V. Epstein, Ihor J. Masnyk, Maureen Hatch, Elaine Ron, Jay H. Lubin, T Bogdanova, John A Robbins, Valentyn V. Markov, Valery A. Olijnyk, Illya A. Likhtarev, Lydia B. Zablotska, Robert J. McConnell, Alina V. Brenner, André Bouville, A. B. Brill |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Neoplasms Radiation-Induced Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry chemistry.chemical_element Context (language use) Iodine Radiation Dosage Biochemistry Autoantigens Iodide Peroxidase Autoimmune thyroiditis Cohort Studies Iodine Radioisotopes Endocrinology Thyroid peroxidase Internal medicine Iron-Binding Proteins Medicine Humans Mass Screening Thyroid Neoplasms Child Thyroid cancer Autoantibodies Autoimmune disease biology business.industry Biochemistry (medical) Thyroid Carcinoma Infant Newborn Thyroiditis Autoimmune Infant medicine.disease Thyroid Diseases medicine.anatomical_structure Cross-Sectional Studies chemistry Chernobyl Nuclear Accident Child Preschool biology.protein Female business Ukraine Cohort study |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 91(11) |
| ISSN: | 0021-972X |
| Popis: | Context: Due to the Chornobyl accident, millions were exposed to radioactive isotopes of iodine and some received appreciable iodine 131 (131I) doses. A subsequent increase in thyroid cancer has been largely attributed to this exposure, but evidence concerning autoimmune thyroiditis (AIT) remains inconclusive. Objective: The objective of the study was to quantify risk of AIT after 131I exposure. Design/Setting/Participants: Baseline data were collected from the first screening cycle (1998–2000) of a large cohort of radiation-exposed individuals (n = 12,240), residents of contaminated, iodine-deficient territories of Ukraine. Study individuals were under the age of 18 yr on April 26, 1986, and had thyroid radioactivity measurements made shortly after the accident. Outcomes: AIT was defined a priori based on various combinations of elevated antibodies to thyroid peroxidase (ATPO), TSH, and clinical findings; elevated ATPO were considered to be an indicator of thyroid autoimmunity. Results: No significant association was found between 131I thyroid dose estimates and AIT, but prevalence of elevated ATPO demonstrated a modest, significant association with 131I that was well described by several concave models. This relationship was apparent in individuals with moderately elevated ATPO and euthyroid, thyroid disease-free individuals. Conclusions: Twelve to 14 yr after the Chornobyl accident, no radiation-related increase in prevalence of AIT was found in a large cohort study, the first in which 131I thyroid doses were estimated using individual radioactivity measurements. However, a dose-response relationship with ATPO prevalence raises the possibility that clinically important changes may occur over time. Thus, further follow-up and analysis of prospective data in this cohort are necessary. |
| Databáze: | OpenAIRE |
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