Trehalose decreases blood clotting in the cerebral space after experimental subarachnoid hemorrhage
| Autor: | Manabu Mochizuki, Nobuo Sasaki, Ung-il Chung, Saori Uchikawa, Nobuyuki Shimohata, Kensuke Karatsu, Shigeki Suzuki, Ryosuke Echigo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Subarachnoid hemorrhage subarachnoid hemorrhage medicine.medical_treatment blood clotting Lipid peroxidation Rats Sprague-Dawley chemistry.chemical_compound Cerebral vasospasm medicine.artery Internal medicine Fibrinolysis medicine Basilar artery Internal Medicine Animals Humans cardiovascular diseases coagulation Blood Coagulation trehalose General Veterinary business.industry Vasospasm medicine.disease Note Trehalose nervous system diseases Disease Models Animal Endocrinology Coagulation chemistry Basilar Artery fibrinolysis Rabbits business circulatory and respiratory physiology |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 0916-7250 |
| Popis: | Subarachnoid hemorrhage (SAH) frequently results in several serious complications, such as cerebral vasospasm. We previously reported the effect of trehalose on vasospasm, inflammatory responses, and lipid peroxidation induced by blood exposure. Herein, to further elucidate the mechanism of action of trehalose, we investigated whether or not post-administration of trehalose can directly influence blood clotting in the cistern. As a result of trehalose injection after the onset of experimental SAH, blood clotting around the basilar artery was clearly inhibited. We also found that trehalose positively impacted coagulation and fibrinolysis parameters in rat, rabbit and human plasma in vitro. These findings suggest that trehalose has suppressive effects on blood clotting in addition to vasospasm, inflammatory responses, and lipid peroxidation after SAH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|