Effects of Crocin on Learning and Memory in Rats Under Chronic Restraint Stress with Special Focus on the Hippocampal and Frontal Cortex Corticosterone Levels
| Autor: | Hajaralsadat Hosseini Dastgerdi, Ali Asghar Pourshanazari, Maryam Radahmadi, Azadehalsadat Hosseini Dastgerdi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Frontal cortex hippocampus Hippocampus lcsh:Medicine Hippocampal formation Foot shock Crocin memory 03 medical and health sciences chemistry.chemical_compound stress 0302 clinical medicine Corticosterone Internal medicine medicine Chronic stress lcsh:QH301-705.5 business.industry lcsh:R General Medicine crocin 030104 developmental biology Endocrinology chemistry lcsh:Biology (General) Original Article Restraint stress business 030217 neurology & neurosurgery |
| Zdroj: | Advanced Biomedical Research Advanced Biomedical Research, Vol 6, Iss 1, Pp 157-157 (2017) |
| ISSN: | 2277-9175 |
| Popis: | Background: Chronic stress adversely influences brain functions while crocin, as an effective component of saffron, exhibits positive effects on memory processes. This study investigated the effects of different doses of crocin on the improvement of learning and memory as well as corticosterone (CORT) levels in the hippocampus and frontal cortex of rats subjected to chronic stress. Materials and Methods: Forty male rats were randomly allocated to five different groups (n = 8): Control, sham; stress (6 h/day for 21 days) groups, and two groups receiving daily intraperitoneal injections of one of two doses (30 and 60 mg/kg) of crocin accompanied by 21 days of restraint stress. Latency was evaluated as a brain function using the passive avoidance test before and one-day after a foot shock. CORT levels were measured in the homogenized hippocampus and frontal cortex. Results: Results revealed that chronic stress had a significantly (P < 0.01) negative effect on memory. Crocin (30 and 60 mg/kg), however, gave increase to significantly (P < 0.01 and P < 0.05; respectively) improved memory functions in the stressed rats. Furthermore, the CORT levels in the hippocampus and frontal cortex declined significantly (P < 0.05) in the stress group compared to the control. Only a crocin dose of 30 mg/kg was observed modulate significantly (P < 0.05) the CORT levels in the hippocampus and frontal cortex in the stressed group. Conclusions: It was found that the lower crocin dose (30 mg/kg) had more beneficial effects than its higher (60 mg/kg) dose on learning and memory under chronic stress conditions. Moreover, it was speculated that different doses of crocin act on different neurotransmitters and biochemical factors in the brain. |
| Databáze: | OpenAIRE |
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