Limitations of Quantitative CT in Corticosteroid Induced Osteopenia
| Autor: | A. H. Karantanas, D. Glaros, John Kalef-Ezra |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Urology Corticosteroid treatment Renal graft 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Spinal Diseases/*chemically induced/radiography Tomography X-Ray Computed Reduction (orthopedic surgery) Collagen disease Radiological and Ultrasound Technology business.industry Prednisolone/*adverse effects Kidney Transplantation/immunology Collagen Diseases/drug therapy General Medicine Middle Aged Bone Diseases Metabolic/*chemically induced/radiography medicine.disease Surgery Osteopenia Transplantation 030220 oncology & carcinogenesis Toxicity Corticosteroid Female business |
| Zdroj: | Acta Radiologica. 32:339-341 |
| ISSN: | 1600-0455 0284-1851 |
| Popis: | Single energy spectrum quantitative CT (SES-QCT) was applied for the assessment of the trabecular bone mineral status in patients under long-term corticosteroid treatment. Seventeen renal graft recipients (RGR) and 12 patients receiving corticosteroid treatment for collagen disease were studied. A reduction of about 40% in the spinal trabecular bone density relative to matched controls was found, associated with the corticosteroid administration. Repeated measurements showed significant reduction in density 4 months after transplantation, and an increase in density after graft rejection. Radiologic or clinical evidence of osteopenia in the spine was not found. Other non-invasive techniques, applied in the upper extremities of the RGR, showed only minor bone reduction compared to controls. The findings of the present study suggest that adipose tissue deposition in the spinal trabeculae can introduce errors in the measurements. Therefore, SES-QCT should not be applied during corticosteroid therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|