β-radiating radionuclides in cancer treatment, novel insight into promising approach
| Autor: | Peter S. Timashev, Leila Nasehi, Nematollah Gheibi, Morteza Mohamadi, Anastasia Shpichka, Mohamad Reza Davarpanah, Moustapha Hassan, Bagher Aziz Kalantari, Samieh Asadian, Massoud Vosough, Hamidreza Aboulkheyr Es, Hamed Mirzaei, Mustapha Najimi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell cycle checkpoint medicine.medical_treatment Targeted radionuclide therapy Cancer therapy Apoptosis Tissue penetration 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Animals Humans Pharmacology Radioisotopes business.industry Cell Cycle Checkpoints Cancer treatment Beta Particles Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Cancer research business |
| Zdroj: | Pharmacological research. 160 |
| ISSN: | 1096-1186 |
| Popis: | Targeted radionuclide therapy, known as molecular radiotherapy is a novel therapeutic module in cancer medicine. β-radiating radionuclides have definite impact on target cells via interference in cell cycle and particular signalings that can lead to tumor regression with minimal off-target effects on the surrounding tissues. Radionuclides play a remarkable role not only in apoptosis induction and cell cycle arrest, but also in the amelioration of other characteristics of cancer cells. Recently, application of novel β-radiating radionuclides in cancer therapy has been emerged as a promising therapeutic modality. Several investigations are ongoing to understand the underlying molecular mechanisms of β-radiating elements in cancer medicine. Based on the radiation dose, exposure time and type of the β-radiating element, different results could be achieved in cancer cells. It has been shown that β-radiating radioisotopes block cancer cell proliferation by inducing apoptosis and cell cycle arrest. However, physical characteristics of the β-radiating element (half-life, tissue penetration range, and maximum energy) and treatment protocol determine whether tumor cells undergo cell cycle arrest, apoptosis or both and to which extent. In this review, we highlighted novel therapeutic effects of β-radiating radionuclides on cancer cells, particularly apoptosis induction and cell cycle arrest. |
| Databáze: | OpenAIRE |
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