Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
| Autor: | Prashant Kesharwani, Harish Rajak, Bapi Gorain, Vijay K. Patel, Talha Jawaid, Mehnaz Kamal, Ekta Shirbhate, Jaiprakash Pandey |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Acute Lung Injury Disease Review Bioinformatics Pathogenesis 03 medical and health sciences 0302 clinical medicine Intervention (counseling) Medicine Humans rhACE2 Receptor Pharmacology Acute respiratory distress syndrome business.industry SARS-CoV-2 COVID-19 General Medicine COVID-19 Drug Treatment 030220 oncology & carcinogenesis Angiotensin-converting enzyme 2 Hypertension Spike Glycoprotein Coronavirus Angiotensin-converting enzyme-2 Cell response Angiotensin-Converting Enzyme 2 business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pharmacological Reports |
| ISSN: | 2299-5684 1734-1140 |
| Popis: | Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin-angiotensin-aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis. |
| Databáze: | OpenAIRE |
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