Spatio‐temporal assessment of illicit drug use at large scale : evidence from 7 years of international wastewater monitoring

Autor: Iria González‐Mariño, Jose Antonio Baz‐Lomba, Nikiforos A. Alygizakis, Maria Jesús Andrés‐Costa, Richard Bade, Anne Bannwarth, Leon P. Barron, Frederic Been, Lisa Benaglia, Jean‐Daniel Berset, Lubertus Bijlsma, Igor Bodík, Asher Brenner, Andreas L. Brock, Daniel A. Burgard, Erika Castrignanò, Alberto Celma, Christophoros E. Christophoridis, Adrian Covaci, Olivier Delémont, Pim Voogt, Damien A. Devault, Mário J. Dias, Erik Emke, Pierre Esseiva, Despo Fatta‐Kassinos, Ganna Fedorova, Konstantinos Fytianos, Cobus Gerber, Roman Grabic, Emma Gracia‐Lor, Stefan Grüner, Teemu Gunnar, Evroula Hapeshi, Ester Heath, Björn Helm, Félix Hernández, Aino Kankaanpaa, Sara Karolak, Barbara Kasprzyk‐Hordern, Ivona Krizman‐Matasic, Foon Yin Lai, Wojciech Lechowicz, Alvaro Lopes, Miren López de Alda, Ester López‐García, Arndís S. C. Löve, Nicola Mastroianni, Gillian L. McEneff, Rosa Montes, Kelly Munro, Thomas Nefau, Herbert Oberacher, Jake W. O'Brien, Reinhard Oertel, Kristin Olafsdottir, Yolanda Picó, Benedek G. Plósz, Fabio Polesel, Cristina Postigo, José Benito Quintana, Pedram Ramin, Malcolm J. Reid, Jack Rice, Rosario Rodil, Noelia Salgueiro‐González, Sara Schubert, Ivan Senta, Susana M. Simões, Maja M. Sremacki, Katarzyna Styszko, Senka Terzic, Nikolaos S. Thomaidis, Kevin V. Thomas, Ben J. Tscharke, Robin Udrisard, Alexander L. N. Nuijs, Viviane Yargeau, Ettore Zuccato, Sara Castiglioni, Christoph Ort
Přispěvatelé: Ministerio de Economía y Competitividad (España), European Commission, López De Alda, Miren, Postigo, Cristina, González-Mariño, Iria, Baz-Lomba, Jose Antonio, Alygizakis, Nikiforos A., Andrés-Costa, Maria Jesús, Bade, Richard, Gerber, Cobus, Ort, Christoph, Freshwater and Marine Ecology (IBED, FNWI), López De Alda, Miren [0000-0002-9347-2765], Postigo, Cristina [0000-0002-7344-7044], Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía, Universidade de Santiago de Compostela. Instituto de Investigación e Análises Alimentarias
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Research Report
Wastewater‐based epidemiology
Ecstasy/MDMA
Epidemiology
medicine.medical_treatment
Ecstasy
Population
Illicit drugs
030508 substance abuse
Medicine (miscellaneous)
Wastewater-based epidemiology
580 Plants (Botany)
Methamphetamine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cocaine
Environmental health
Amphetamine
cocaine
ecstasy
MDMA
illicit drugs
methamphetamine
wastewater-based epidemiology
Illicit drug
Medicine
030212 general & internal medicine
education
wastewater‐based epidemiology
education.field_of_study
business.industry
Pharmacology. Therapy
Research Reports
6. Clean water
3. Good health
Stimulant
Psychiatry and Mental health
Interdisciplinary Natural Sciences
chemistry
Wastewater
Environmental Science
Benzoylecgonine
0305 other medical science
business
medicine.drug
Zdroj: Addiction
González-Mariño, Iria; Baz-Lomba, Jose Antonio; Alygizakis, Nikiforos A.; Andrés-Costa, Maria Jesús; Bade, Richard; Barron, Leon P.; Been, Frederic; Berset, Jean-Daniel; Bijlsma, Lubertus; Bodík, Igor; Brenner, Asher; Brock, Andreas L.; Burgard, Daniel A.; Castrignanò, Erika; Christophoridis, Christophoros E.; Covaci, Adrian; Voogt, Pim; Devault, Damien A.; Dias, Mário J.; Emke, Erik; ... (2020). Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring. Addiction, 115(1), pp. 109-120. Wiley-Blackwell 10.1111/add.14767
González-Mariño, I, Baz-Lomba, J A, Alygizakis, N A, Andrés-Costa, M J, Bade, R, Barron, L P, Been, F, Berset, J-D, Bijlsma, L, Bodík, I, Brenner, A, Brock, A L, Burgard, D A, Castrignanò, E, Christophoridis, C E, Covaci, A, de Voogt, P, Devault, D A, Dias, M J, Emke, E, Fatta-Kassinos, D, Fedorova, G, Fytianos, K, Gerber, C, Grabic, R, Grüner, S, Gunnar, T, Hapeshi, E, Heath, E, Helm, B, Hernández, F, Kankaanpaa, A, Karolak, S, Kasprzyk-Hordern, B, Krizman-Matasic, I, Lai, F Y, Lechowicz, W, Lopes, A, López de Alda, M, López-García, E, Löve, A S C, Mastroianni, N, McEneff, G L, Montes, R, Munro, K, Nefau, T, Oberacher, H, O'Brien, J W, Olafsdottir, K, Picó, Y, Plósz, B G, Polesel, F, Postigo, C, Quintana, J B, Ramin, P, Reid, M J, Rice, J, Rodil, R, Senta, I, Simões, S M, Sremacki, M M, Styszko, K, Terzic, S, Thomaidis, N S, Thomas, K V, Tscharke, B J, van Nuijs, A L N, Yargeau, V, Zuccato, E, Castiglioni, S & Ort, C 2020, ' Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring ', Addiction, vol. 115, no. 1 . https://doi.org/10.1111/add.14767
Repositori Universitat Jaume I
Universitat Jaume I
Addiction, 115(1), 109-120. Wiley-Blackwell
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Addiction, vol. 115, no. 1, pp. 109-120
Addiction (Abingdon, England)
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
ISSN: 0965-2140
DOI: 10.1111/add.14767
Popis: Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population‐normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. Design Analysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to 2017. Setting and Participants Catchment areas of 143 wastewater treatment plants in 120 cities in 37 countries. Measurements Parent substances (amphetamine, methamphetamine and MDMA) and the metabolites of cocaine (benzoylecgonine) and of Δ9‐tetrahydrocannabinol (11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol) were measured in wastewater using liquid chromatography–tandem mass spectrometry. Daily mass loads (mg/day) were normalized to catchment population (mg/1000 people/day) and converted to the number of combined doses consumed per day. Spatial differences were assessed world‐wide, and temporal trends were discerned at European level by comparing 2011–13 drug loads versus 2014–17 loads. Findings Benzoylecgonine was the stimulant metabolite detected at higher loads in southern and western Europe, and amphetamine, MDMA and methamphetamine in East and North–Central Europe. In other continents, methamphetamine showed the highest levels in the United States and Australia and benzoylecgonine in South America. During the reporting period, benzoylecgonine loads increased in general across Europe, amphetamine and methamphetamine levels fluctuated and MDMA underwent an intermittent upsurge. Conclusions The analysis of wastewater to quantify drug loads provides near real‐time drug use estimates that globally correspond to prevalence and seizure data.
This study was supported by the following countries, institutions and projects Australia: Thyne Reid foundation; Canada: Natural Sciences and Engineering Research Council of Canada (NSERC); Iceland: The Icelandic Research Fund (Grant number 163049–051); Slovenia: Slovene Research Agency (funding Project L1–9191); Spain: MINECO/AEI projects (CTM2014–56628‐C3–2‐R, CTQ2015–65603‐P, CTM2016–81935‐REDT, CTM2017–84763‐C3–2‐R), Galician Council of Culture, Education and Universities (ED481D 2017/003); UK: Environmental Sustainability Knowledge Transfer Network, Engineering and Physical Sciences Research Council and Thermo Fisher Scientific (CASE industrial scholarship for K. Munro, Ref.: EP/J502029/1). European Monitoring Centre for Drugs and Drug Addiction (EMCDDA); EU International Training Network SEWPROF (Marie Curie‐FP7‐PEOPLE, grant number 317205); COST Action ES1307 supported by COST (European Cooperation in Science and Technology); WATCH (Wastewater Analysis of Traces of illicit drug‐related Chemicals for law enforcement and public Health DG migration and Home affairs ‐ HOME/2015/ISFP/PR/DRUG/0062). Sampling support and provision of catchment information Austria: Klemens Geiger and Michael Schlapp; Belgium: Jonathan Phariseau, Bart Coene, Luc Van Os, Peter Nys, Dieter Lemaire, Jean‐François Mougel, Patrick Vantroyen and Karel Claes; Croatia: Marin Ganjto; Czech Republic: Jiri Stara and Robert Hrich Brněnské; France: Véronique Bremont; Italy: Roberto Mazzini and Francesca Pizza (Milan), Francesco Avolio (Bologna), Fabrizio Moratto and Sergio Ghezzi (Gorizia), Rosanna Brienza and Simona Panariello (Potenza), Pier Paolo Abis and Antonia Attanasio (Bari), Antonella Cicala (Palermo); Norway: Pia Ryrfors; Portugal: João Goulão, José Martins, Pedro Alvaro and Fátima Paixão; Slovakia: Silvia Antalová and Jozef Tichy; Spain: Begoña Martínez López, Cristian Mesa, Santiago Querol Rodriguez, Fernando Llavador, Enrique Albors and Gloria Fayos; the Netherlands: Alex Veltman, Peter Theijssen, Peter van Dijk, Stefan Wijers, Mark Stevens, Ferry de Wilde. Analytical support Australia: Maulik Ghetia; Cyprus: Popi Karaolia; Greece: Nikoilaos Raikos; Spain: Ana Maria Botero‐Coy, Clara Boix, Alberto Celma, Jorge Pitarch, Inés Racamonde and Eddie Fonseca; Italy: Emma Gracia‐Lor, Nikolaos I. Rousis and Noelia Salgueiro‐Gonzalez. Data repository and data screening Eawag: Harald von Waldow; EMCDDA: Renate Hochwieser, Liesbeth Vandam, João Matias and Federica Mathis.
Databáze: OpenAIRE
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