Therapeutic drug monitoring of tumour necrosis factor inhibitors in the management of chronic inflammatory diseases
| Autor: | Noemí Rebollo, Ana Martín-Suárez, Fernando Muñoz, José Germán Sánchez-Hernández, M. V. Calvo |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
030213 general clinical medicine medicine.medical_specialty media_common.quotation_subject Clinical Biochemistry Anti-Inflammatory Agents 030209 endocrinology & metabolism Etanercept Cohort Studies 03 medical and health sciences 0302 clinical medicine Adalimumab Humans Medicine Intensive care medicine Disease burden media_common Inflammation medicine.diagnostic_test Tumor Necrosis Factor-alpha business.industry Antibodies Monoclonal General Medicine Guideline Infliximab Systematic review Therapeutic drug monitoring Chronic Disease Drug Monitoring business Systematic Reviews as Topic medicine.drug |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 56:28-41 |
| ISSN: | 1758-1001 0004-5632 |
| Popis: | Tumour necrosis factor inhibitor therapy has drastically changed the management of chronic inflammatory diseases. Some important drawbacks that can cause loss of response during treatment with these drugs are related to their large individual variability, the disease burden and the formation of antidrug antibodies that increase its clearance. Therapeutic drug monitoring of these drugs is not yet recommended by all scientific societies, and if so, only in patients with inflammatory symptoms. Proactive therapeutic drug monitoring represents a new strategy with many potential clinical benefits, including the prevention of immunogenicity, a reduction in the need for rescue therapy and greater durability of tumour necrosis factor inhibitor treatment. The review is based on a systematic search of the literature for controlled trials, systematic reviews, experimental studies, guideline papers and cohort studies addressing the best practice in tumour necrosis factor inhibitor therapeutic drug monitoring. Although there is ample evidence supporting the use of therapeutic drug monitoring in clinical practice to achieve better outcomes, some challenges have been detected. Many studies are focused on finding solutions for the lack of standardization of analytical methods to measure tumour necrosis factor inhibitor and antidrug antibodies concentrations. Other challenges are development of effective cost-saving proactive algorithms to identify optimal drug concentrations and the research on the role of antidrug antibodies, especially in the management and prevention of loss of response. Therapeutic drug monitoring of tumour necrosis factor inhibitor offers a rational approach to the optimization of the treatment of chronic inflammatory disease. Although prospective controlled trials yield little conclusive evidence of its benefits, there is growing acceptance of its value in clinical practice. |
| Databáze: | OpenAIRE |
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