Malaria transmission-blocking vaccines: wheat germ cell-free technology can accelerate vaccine development
| Autor: | Tomoko Ishino, Hikaru Nagaoka, Mayumi Tachibana, Takafumi Tsuboi, Eizo Takashima, Kazutoyo Miura, Masayuki Morita, Bernard N. Kanoi, Minami Baba, Motomi Torii |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Databases Factual Plasmodium falciparum Immunology Protozoan Proteins Cell free 03 medical and health sciences Immunogenicity Vaccine 0302 clinical medicine Malaria transmission Malaria elimination Malaria Vaccines parasitic diseases Drug Discovery Humans Medicine 030212 general & internal medicine Malaria Falciparum Triticum Pharmacology Cell-Free System biology business.industry Malaria vaccine Immunogenicity Wheat germ biology.organism_classification medicine.disease Recombinant Proteins Malaria Germ Cells 030104 developmental biology Molecular Medicine business |
| Zdroj: | Expert Review of Vaccines. 18:1017-1027 |
| ISSN: | 1744-8395 1476-0584 |
| Popis: | Introduction: Highly effective malaria vaccines are essential component toward malaria elimination. Although the leading malaria vaccine, RTS,S/AS01, with modest efficacy is being evaluated in a pilot feasibility trial, development of a malaria transmission-blocking vaccine (TBV) could make a major contribution toward malaria elimination. Only a few TBV antigens have reached pre-clinical or clinical development but with several challenges including difficulties in the expression of malaria recombinant proteins and low immunogenicity in humans. Therefore, novel approaches to accelerate TBV research to preclinical development are critical to generate an efficacious TBV.Areas covered: PubMed was searched to review the progress and future prospects of malaria TBV research and development. We also reviewed registered trials at ClinicalTrials.gov as well as post-genome TBV candidate discovery research including our efforts.Expert opinion: Wheat germ cell-free protein synthesis technology can accelerate TBV development by overcoming some current challenges of TBV research. |
| Databáze: | OpenAIRE |
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