Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

Autor: Agnès Ferroni, Justine Dautremer, Nicolas Degand, Julie Bruneau, Fanny Lanternier, Marc Lecuit, Olivier Hermine, Olivier Lortholary, Stéphane Blanche, Benoit Pilmis, Xavier Nassif
Přispěvatelé: Laboratoire de Microbiologie [AP-HP Necker], Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des Maladies infectieuses et tropicales [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Service d'AnatomoPathologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Hématologie Adulte, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Université Paris Descartes - Paris 5 (UPD5), Service d'immuno-hématologie pédiatrique [CHU Necker], We thank Agnès Labigne, Unité de Pathogénie bactérienne des muqueuses, Institut Pasteur, Paris, France, for her help in this case report., Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP]-Institut des Maladies Génétiques Imagine [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP]
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
MESH: Helicobacter Infections/pathology
MESH: Agammaglobulinemia/pathology
[SDV]Life Sciences [q-bio]
Azithromycin
Bruton’s disease
Gastroenterology
Medical microbiology
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Helicobacter
Immunology and Allergy
MESH: Anti-Bacterial Agents/therapeutic use
MESH: Agammaglobulinemia/drug therapy
MESH: Genetic Diseases
X-Linked/pathology
medicine.diagnostic_test
biology
MESH: Helicobacter Infections/drug therapy
Suppurative cholangitis
Genetic Diseases
X-Linked
3. Good health
Anti-Bacterial Agents
cholangitis
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Liver
MESH: Young Adult
Liver biopsy
[SDV.IMM]Life Sciences [q-bio]/Immunology
medicine.drug
Helicobacter bilis
DNA
Bacterial
medicine.medical_specialty
030106 microbiology
Immunology
MESH: Genetic Diseases
X-Linked/drug therapy
DNA
Ribosomal
Helicobacter Infections
MESH: Liver/pathology
03 medical and health sciences
Young Adult
MESH: Helicobacter/genetics
Internal medicine
medicine
MESH: Helicobacter Infections/microbiology
Humans
Colitis
MESH: DNA
Ribosomal/genetics
MESH: Humans
business.industry
MESH: Agammaglobulinemia/microbiology
MESH: Genetic Diseases
X-Linked/microbiology
biology.organism_classification
medicine.disease
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
MESH: Male
MESH: DNA
Bacterial/genetics
agammaglobulinemia
Metronidazole
MESH: Cholangitis/pathology
030104 developmental biology
MESH: Cholangitis/drug therapy
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
MESH: Cholangitis/microbiology
Zdroj: Journal of Clinical Immunology
Journal of Clinical Immunology, Springer Verlag, 2017, 37 (7), pp.727-731. ⟨10.1007/s10875-017-0437-z⟩
Journal of Clinical Immunology, 2017, 37 (7), pp.727-731. ⟨10.1007/s10875-017-0437-z⟩
ISSN: 0271-9142
1573-2592
Popis: International audience; Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases. Purpose : We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis. Methods : 16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis. Results : Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin. Conclusion : In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.
Databáze: OpenAIRE
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