The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?
| Autor: | Adria Perez Rovira, Marleen de Bruijne, Leonie A. Tepper, Daan Caudri, Harm A.W.M. Tiddens |
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| Přispěvatelé: | Pediatrics, Radiology & Nuclear Medicine, Medical Informatics |
| Jazyk: | angličtina |
| Předmět: |
Adult
Male High-resolution computed tomography medicine.medical_specialty Adolescent Cystic Fibrosis Atelectasis Cystic fibrosis 03 medical and health sciences Young Adult 0302 clinical medicine Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Longitudinal Studies Child Lung Neuroradiology Retrospective Studies Observer Variation Bronchiectasis medicine.diagnostic_test business.industry Interventional radiology Paediatrics General Medicine respiratory system medicine.disease Mucus nervous system diseases medicine.anatomical_structure 030228 respiratory system Radiology Nuclear Medicine and imaging Lung disease Disease Progression High resolution computed tomography Female Radiology business Tomography X-Ray Computed |
| Zdroj: | European Radiology, 26(12), 4563-4569. Springer-Verlag European Radiology Tepper, L A, Caudri, D, Rovira, A P, Tiddens, H A W M & de Bruijne, M 2016, ' The development of bronchiectasis on chest computed tomography in children with cystic fibrosis : can pre-stages be identified? ', European Radiology, vol. 26, no. 12, pp. 4563-4569 . https://doi.org/10.1007/s00330-016-4329-z |
| ISSN: | 0938-7994 |
| DOI: | 10.1007/s00330-016-4329-z |
| Popis: | Objective Bronchiectasis is an important component of cystic fibrosis (CF) lung disease but little is known about its development. We aimed to study the development of bronchiectasis and identify determinants for rapid progression of bronchiectasis on chest CT. Methods Forty-three patients with CF with at least four consecutive biennial volumetric CTs were included. Areas with bronchiectasis on the most recent CT were marked as regions of interest (ROIs). These ROIs were generated on all preceding CTs using deformable image registration. Observers indicated whether: bronchiectasis, mucus plugging, airway wall thickening, atelectasis/consolidation or normal airways were present in the ROIs. Results We identified 362 ROIs on the most recent CT. In 187 (51.7 %) ROIs bronchiectasis was present on all preceding CTs, while 175 ROIs showed development of bronchiectasis. In 139/175 (79.4 %) no pre-stages of bronchiectasis were identified. In 36/175 (20.6 %) bronchiectatic airways the following pre-stages were identified: mucus plugging (17.7 %), airway wall thickening (1.7 %) or atelectasis/consolidation (1.1 %). Pancreatic insufficiency was more prevalent in the rapid progressors compared to the slow progressors (p = 0.05). Conclusion Most bronchiectatic airways developed within 2 years without visible pre-stages, underlining the treacherous nature of CF lung disease. Mucus plugging was the most frequent pre-stage. Key Points • Development of bronchiectasis in cystic fibrosis lung disease on CT. • Most bronchiectatic airways developed within 2 years without pre-stages. • The most frequently identified pre-stage was mucus plugging. • This study underlines the treacherous nature of CF lung disease. Electronic supplementary material The online version of this article (doi:10.1007/s00330-016-4329-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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