Urinary excretion of diazepam metabolites in healthy volunteers and drug users
| Autor: | K. M. Olsen, A. Smith-Kielland, B. Skuterud, Jørg Mørland |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Drug Chromatography Gas Substance-Related Disorders Metabolite media_common.quotation_subject Nordazepam Clinical Biochemistry Urine Pharmacology Excretion Temazepam chemistry.chemical_compound medicine Humans Volunteer Chromatography High Pressure Liquid media_common Creatinine Diazepam Oxazepam Chemistry General Medicine Middle Aged Substance Abuse Detection Anti-Anxiety Agents Female medicine.drug |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 61:237-246 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/003655101300133676 |
| Popis: | Urinary excretion profiles of diazepam metabolites were investigated. The subjects were healthy volunteers receiving one single 10-mg dose of diazepam or drug abusers starting a prison sentence. Urinary excretion of metabolites was analysed by immunological screening, liquid chromatography and gas chromatography-mass spectrometry. Relating the metabolite concentration to creatinine concentration in the specimens decreased sample-to-sample variations. In some cases such correction could protect a subject from erroneous accusations of a new intake. |
| Databáze: | OpenAIRE |
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