Evaluation of bone healing activity of Cissus quadrangularis (Linn), Cryptolepis buchanani, and Sardinella longiceps in Wistar rats
| Autor: | Magharla Dasaratha Dhanaraju, Laith Fadhil, Somasundaram Ramachandran, Masa Amala, Chandravadivelu Gopi |
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| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
Science Pharmaceutical Science Medicine (miscellaneous) chemistry.chemical_element Bone healing Calcium Fractured bone 03 medical and health sciences R5-920 0404 agricultural biotechnology 0302 clinical medicine Cissus quadrangularis Medicine Femur Sardinella Sardinella longiceps biology Traditional medicine business.industry Cryptolepis Femur bone healing 030206 dentistry 04 agricultural and veterinary sciences Cryptolepis buchanani biology.organism_classification 040401 food science Agricultural and Biological Sciences (miscellaneous) chemistry Femur bone business |
| Zdroj: | Beni-Suef University Journal of Basic and Applied Sciences, Vol 10, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2314-8543 |
| DOI: | 10.1186/s43088-021-00120-z |
| Popis: | Background The object of the present study is to evaluate the effect of alcoholic extracts of Cissus quadrangularis (CQ), Cryptolepis buchanani (CB), and Sardinella longiceps (SL) either alone or in the combination (100 mg/kg) in the management of femur bone healing of Wistar albino rats for 8 weeks. After the period of treatment, femur bones were examined by using biochemical, radiographical, and histopathological studies. Result Biochemical evaluation results reveal that there is a steep increase of serum calcium level in the experimental animals during the entire period of treatment which led to an adequate supply of serum calcium to the fractured bone for healing and increases the thickness of the femur bones soon compared to control group. It had been estimated by a calibrated ocular micrometer. Radiographical images of the bones also disclose that the complete bridging of fractured bone occurred in the experimental animals after the treatment of natural compound extracts. In addition to that, all the organs of animals were safe in the experimental animals during the entire study. Conclusion The present study strongly recommended that these ethanolic extracts (CQCBSL) either alone or in the combination restoring the strength of the bone and reduced bone repairing period due to the rich content of calcium and other natural phytochemicals presents with them. Graphical abstract |
| Databáze: | OpenAIRE |
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