A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder
| Autor: | Aman Mangalmurti, Tonya White, Gabriel A. Devenyi, Devon Shook, Steven William Kasparek, Gustavo Sudre, Chava Zibman, Kerstin Konrad, Min Tae M. Park, Sarah Durston, Georg von Polier, Ryan L. Muetzel, Philip Shaw, M. Mallar Chakravarty, Martine Hoogman, Ayaka Ishii-Takahashi, Henning Tiemeier |
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| Přispěvatelé: | Child and Adolescent Psychiatry / Psychology, Radiology & Nuclear Medicine |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Longitudinal study Cerebellum medicine.medical_specialty Adolescent neuroanatomy growth Neuroimaging Audiology Pediatrics Article White matter Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center medicine Developmental and Educational Psychology Attention deficit hyperactivity disorder Humans Early childhood Longitudinal Studies Pediatrics Perinatology and Child Health Child Netherlands Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] Age Factors Cognition medicine.disease Perinatology Comorbidity 030227 psychiatry and Child Health meta-analysis Psychiatry and Mental health medicine.anatomical_structure attention deficit hyperactivity disorder Attention Deficit Disorder with Hyperactivity Child Preschool Pediatrics Perinatology and Child Health Cerebellar vermis Female Psychology white matter 030217 neurology & neurosurgery |
| Zdroj: | Journal of Child Psychology and Psychiatry and Allied Disciplines, 59, 1114-1123 Journal of Child Psychology and Psychiatry and Allied Disciplines, 59(10), 1114. Wiley-Blackwell Journal of Child Psychology and Psychiatry, 59(10), 1114-1123. Wiley-Blackwell Publishing Ltd Journal of Child Psychology and Psychiatry and Allied Disciplines, 59, 10, pp. 1114-1123 |
| ISSN: | 1469-7610 0021-9630 1114-1123 |
| DOI: | 10.1111/jcpp.12920 |
| Popis: | Background: The cerebellum supports many cognitive functions disrupted in attention deficit hyperactivity disorder (ADHD). Prior neuroanatomic studies have been often limited by small sample sizes, inconsistent findings, and a reliance on cross-sectional data, limiting inferences about cerebellar development. Here, we conduct a multicohort study using longitudinal data, to characterize cerebellar development. Methods: Growth trajectories of the cerebellar vermis, hemispheres and white matter were estimated using piecewise linear regression from 1,656 youth; of whom 63% had longitudinal data, totaling 2,914 scans. Four cohorts participated, all contained childhood data (age 4–12 years); two had adolescent data (12–25 years). Growth parameters were combined using random-effects meta-analysis. Results: Diagnostic differences in growth were confined to the corpus medullare (cerebellar white matter). Here, the ADHD group showed slower growth in early childhood compared to the typically developing group (left corpus medullare z = 2.49, p =.01; right z = 2.03, p =.04). This reversed in late childhood, with faster growth in ADHD in the left corpus medullare (z = 2.06, p =.04). Findings held when gender, intelligence, comorbidity, and psychostimulant medication were considered. Discussion: Across four independent cohorts, containing predominately longitudinal data, we found diagnostic differences in the growth of cerebellar white matter. In ADHD, slower white matter growth in early childhood was followed by faster growth in late childhood. The findings are consistent with the concept of ADHD as a disorder of the brain's structural connections, formed partly by developing cortico-cerebellar white matter tracts. |
| Databáze: | OpenAIRE |
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