Human Marginal Zone B Cells
| Autor: | Claude-Agnès Reynaud, Jean-Claude Weill, Sandra K. Weller |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Lineage (genetic)
Lymphoid Tissue Somatic cell Immunology B-cell receptor Population B-Lymphocyte Subsets Receptors Antigen B-Cell Somatic hypermutation Biology Hyper-IgM Immunodeficiency Syndrome Mice medicine Animals Humans Immunology and Allergy education B cell Gene Rearrangement Genetics education.field_of_study Toll-Like Receptors Immunoglobulin D Gene rearrangement Marginal zone Tumor Necrosis Factor Receptor Superfamily Member 7 medicine.anatomical_structure Immunoglobulin M Immunologic Memory |
| Zdroj: | Annual Review of Immunology. 27:267-285 |
| ISSN: | 1545-3278 0732-0582 |
| Popis: | Human marginal zone (MZ) B cells are, in a sense, a new entity. Although they share many properties with their mouse counterpart, they also display striking differences, such as the capacity to recirculate and the presence of somatic mutations in their B cell receptor. These differences are the reason they are often not considered a separate, rodent-like B cell lineage, but rather are considered IgM memory B cells. We review here our present knowledge concerning this subset and the arguments in favor of the proposition that humans have evolved for their MZ B cell compartment a separate B cell population that develops and diversifies its Ig receptor during ontogeny outside T-dependent or T-independent immune responses. |
| Databáze: | OpenAIRE |
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