Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response
| Autor: | Andrew R. Green, Steve Chan, C. C. Nolan, Emad A. Rakha, Nouf Alsubhi, Ian O. Ellis, Dena A. Jerjees, Alaa T. Alshareeda, Methaq Mueen Al-Kaabi, Abir A. Muftah, Srinivasan Madhusudan, Eleanor Cornford |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
alpha Karyopherins Cytoplasm Cancer Research Nottingham Breast Cancer Research Centre Adolescent CHK1 chemotherapy response Breast Neoplasms Biology Young Adult breast cancer Breast cancer Biomarkers Tumor medicine Humans CHEK1 Phosphorylation Molecular Diagnostics Protein kinase B Aged Cell Nucleus Regulation of gene expression Tissue microarray Middle Aged G2-M DNA damage checkpoint medicine.disease Survival Analysis Gene Expression Regulation Neoplastic Treatment Outcome Oncology immunohistochemistry Checkpoint Kinase 1 Immunology Cancer research Biomarker (medicine) Female Signal transduction Protein Kinases Signal Transduction |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background: Checkpoint kinase1 (CHK1), which is a key component of DNA-damage-activated checkpoint signalling response, may have a role in breast cancer (BC) pathogenesis and influence response to chemotherapy. This study investigated the clinicopathological significance of phosphorylated CHK1 (pCHK1) protein in BC. Method: pCHK1 protein expression was assessed using immunohistochemistry in a large, well-characterized annotated series of early-stage primary operable invasive BC prepared as tissue microarray (n=1200). Result: pCHK1 showed nuclear and/or cytoplasmic expression. Tumours with nuclear expression showed positive associations with favourable prognostic features such as lower grade, lower mitotic activity, expression of hormone receptor and lack of expression of KI67 and PI3K (P |
| Databáze: | OpenAIRE |
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