An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae
| Autor: | Shui-Gen Guo, Chun-Feng Pan, Xu-Feng Lu, De-Jie Chu, Zhu-Yuan Yu, Jing Wang, Yong Du |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Lung Neoplasms Epidemiology medicine.disease_cause law.invention chemistry.chemical_compound law medicine Carcinoma Animals Benzopyrenes Rats Wistar Lung cancer Chlamydophila Infections Polymerase chain reaction Lung Chlamydia biology Public Health Environmental and Occupational Health Chlamydophila pneumoniae medicine.disease Antibodies Bacterial Rats Disease Models Animal medicine.anatomical_structure Oncology Benzo(a)pyrene chemistry biology.protein Antibody |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 13:2819-2822 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2012.13.6.2819 |
| Popis: | Objective: To assess induction effects of Chlamydia pneumoniae (Cpn) on lung cancer in rats. Methods: A lung cancer animal model was developed through repeated intratracheal injection of Cpn (TW-183) into the lungs of rats, with or without exposure to benzo(a)pyrene (Bp). Cpn antibodies (Cpn-IgA, -IgG, and -IgM) in serum were measured by microimmunofluorescence. Cpn-DNA or Cpn-Ag of rat lung cancer was detected through polymerase chain reaction or enzyme-linked immunosorbent assay. Results: The prevalence of Cpn infection was 72.9% (35/48) in the Cpn group and 76.7% (33/43) in the Cpn plus benzo(a)pyrene (Bp) group, with incidences of lung carcinomas in the two groups of 14.6% (7/48) and 44.2% (19/43), respectively (P-values 0.001 and |
| Databáze: | OpenAIRE |
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