Combined Insulin Pump Therapy with Real-Time Continuous Glucose Monitoring Significantly Improves Glycemic Control Compared to Multiple Daily Injection Therapy in Pump Naïve Patients with Type 1 Diabetes; Single Center Pilot Study Experience
| Autor: | Debbie Clausen, Charles Brinegar, Anthony Firek, Tom Sweeney, Allen Hassen, Scott W. Lee, Celia Kolbach, Jerrold S. Petrofsky |
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| Rok vydání: | 2007 |
| Předmět: |
Insulin pump
Type 1 diabetes medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Incidence (epidemiology) Insulin medicine.medical_treatment Biomedical Engineering 030209 endocrinology & metabolism Bioengineering medicine.disease Single Center Surgery Clinical Applications 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Anesthesia Internal Medicine medicine 030212 general & internal medicine Minimed Paradigm business Glycemic |
| Zdroj: | Journal of Diabetes Science and Technology. 1:400-404 |
| ISSN: | 1932-2968 |
| Popis: | Objectives: This study assessed the safety and clinical effectiveness of the training protocol for initiating insulin pump therapy with real-time continuous glucose monitoring (MiniMed Paradigm REAL-Time System) in a stepwise approach on pump naive subjects with type 1 diabetes compared to a control group who remained on multiple daily injection (MDI) therapy. Methods: This was a 15-week treat-to-target pilot study of 16 adult subjects (n = 50% male, age 45.9 ± 16 years) with type 1 diabetes (duration of diabetes 21.9 ± 11 years) on MDI therapy with hemoglobin A1c levels at or above 7.5% at baseline. Subjects were randomized to either the study arm (using a combined insulin pump and real-time continuous glucose monitoring system) or the control arm [which continued on MDI therapy with self-monitored blood glucose (SMBG) only]. All subjects dosed insulin according to results of SMBG by finger stick and uploaded data into the CareLink data management software. Results: Significant improvements in glycemic control were observed from baseline in both study groups—study arm: pre-A1c 9.45 ± 0.55 and post-A1c 7.4 ± 0.66 ( p = 0.00037); control arm: pre-A1c 8.58 ± 1.30 and post-A1c 7.5 ±1.01 ( p = 0.04). Both arms had no incidence of severe hypoglycemia. Conclusion: In this pilot study, the Paradigm REAL-Time System was initiated safely and effectively in type 1 diabetes patients who were pump naïve using a stepwise educational protocol. |
| Databáze: | OpenAIRE |
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