Association of adverse childhood environment and 5-HTTLPR Genotype with late-life depression
| Autor: | Marie-Laure Ancelin, Robert Stewart, Isabelle Jaussent, Anne-Marie Dupuy, Karen Ritchie, Alain Malafosse, Philippe Courtet |
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| Přispěvatelé: | Villebrun, Dominique, Longévité et vieillissement - Interaction entre la vulnérabilité génétique, la dysrégulation biologique et le stress dans la dépression du sujet âgé - - ESPRIT-VIE2007 - ANR-07-LVIE-0004 - LVIE - VALID, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institute of Psychiatry, Queen Mary University of London (QMUL)-King‘s College London, Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Pôle de Psychiatrie, Faculté de Médecine-IFR10-Groupe hospitalier Henri Mondor-Albert Chenevier, Département de Psychiatrie, Geneva University Hospital (HUG)-Hôpital Belle-Idée, Région Languedoc Roussillon, Novartis, ANR-07-LVIE-0004,ESPRIT-VIE,Interaction entre la vulnérabilité génétique, la dysrégulation biologique et le stress dans la dépression du sujet âgé(2007), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Child abuse
Male MESH: Psychiatric Status Rating Scales child abuse [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Poison control Child of Impaired Parents/psychology/statistics & numerical data Verbal abuse 5-HTTLPR Social Environment France/epidemiology Psychiatric Status Rating Scales/statistics & numerical data MESH: Genotype ddc:616.89 0302 clinical medicine MESH: Aged 80 and over Child of Impaired Parents MESH: Risk Factors Risk Factors MESH: Child Longitudinal Studies MESH: Serotonin Plasma Membrane Transport Proteins MESH: Longitudinal Studies Child Depression (differential diagnoses) MESH: Social Environment MESH: Aged Aged 80 and over Serotonin Plasma Membrane Transport Proteins education.field_of_study Adult Survivors of Child Abuse 1. No poverty Age Factors MESH: Stress Psychological Late life depression 3. Good health Life Change Events Psychiatry and Mental health depression Female France Serotonin Plasma Membrane Transport Proteins/*genetics Clinical psychology Adult medicine.medical_specialty Genotype Adult Survivors of Child Abuse/*psychology/*statistics & numerical data Population MESH: Child of Impaired Parents MESH: Depressive Disorder Major Depressive Disorder Major/epidemiology/*genetics elderly Article 03 medical and health sciences Injury prevention MESH: Polymorphism Genetic medicine MESH: Adult Survivors of Child Abuse Humans Psychiatry education Aged Retrospective Studies MESH: Age Factors Psychiatric Status Rating Scales Depressive Disorder Major MESH: Humans Polymorphism Genetic business.industry MESH: Adult MESH: Retrospective Studies MESH: Male 030227 psychiatry gene-environment interaction MESH: France [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Life Change Events [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Journal of Clinical Psychiatry Journal of Clinical Psychiatry, the American Society of Clinical Psychopharmacology, 2009, 70 (9), pp.1281-8. ⟨10.4088/JCP.08m04510⟩ Journal of Clinical Psychiatry, Physicians Postgraduate Press, 2009, 70 (9), pp.1281-8. ⟨10.4088/JCP.08m04510⟩ Journal of Clinical Psychiatry, Vol. 70, No 9 (2009) pp. 1281-1288 |
| ISSN: | 0160-6689 1555-2101 |
| DOI: | 10.4088/JCP.08m04510⟩ |
| Popis: | International audience; OBJECTIVE: Neurobiological and clinical studies suggest that childhood maltreatment may result in functional and structural nervous system changes that predispose the individual to depression. This vulnerability appears to be modulated by a polymorphism in the serotonin gene-linked promoter region (5-HTTLPR). Little is known, however, about the persistence of this vulnerability across the life span, although clinical studies of adult populations suggest that gene-environment interaction may diminish with aging. METHOD: Depressive symptomatology and adverse and protective childhood events were examined in a population of 942 persons aged 65 years and older, taking into account sociodemographic characteristics and proximal competing causes of depression (widowhood, recent life events, vascular and neurologic disorder, and disability). Subjects were recruited between March 1999 and February 2001 and were diagnosed as depressed if they met 1 of 3 criteria: a diagnosis of major depression on the Mini-International Neuropsychiatric Interview, a score higher than 16 on the Center for Epidemiologic Studies-Depression Scale, or current treatment with an antidepressant. RESULTS: Exposure to traumatic events in childhood doubled the risk of late-life depression and increased the risk of repeated episodes. Not all events were found to be pathogenic; significant risk was associated with excessive sharing of parental problems, poverty or financial difficulties, mental disorder in parents, excessive physical punishment, verbal abuse from parents, humiliation, and mistreatment by an adult outside the family. Interactions were observed between the 5-HTTLPR long (L) allele, poverty, and excessive sharing of parental problems. CONCLUSIONS: Certain types of childhood trauma continue to constitute risk factors for depression in old age, outweighing more proximal causes. Gene environment vulnerability interaction is linked in older age to the L-carrying genotype, modulating the effects of general environmental conditions rather than aggressive acts on the individual, perhaps due to increased cardiac reactivity. |
| Databáze: | OpenAIRE |
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