Genome-wide Association Study for Tumour Stage, Grade, Size, and Age at Diagnosis of Non-muscle-invasive Bladder Cancer

Autor: Lambertus A. Kiemeney, Nadezda Lipunova, Anke Wesselius, Jean-Baptiste Cazier, Maurice P. Zeegers, Kar Keung Cheng, Richard T. Bryan, Frederik J. van Schooten, Tessel E. Galesloot
Přispěvatelé: Promovendi NTM, Genetica & Celbiologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, Farmacologie en Toxicologie, RS: CAPHRI - R5 - Optimising Patient Care
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Oncology
Stage
PROGNOSIS
Grade
030232 urology & nephrology
Genome-wide association study
SUSCEPTIBILITY
VARIANTS
0302 clinical medicine
Size
IMPUTATION
Aged
80 and over
Age Factors
Middle Aged
Tumor Burden
Urological cancers Radboud Institute for Health Sciences [Radboudumc 15]
030220 oncology & carcinogenesis
Cohort
Female
Adult
medicine.medical_specialty
CLINICAL-OUTCOMES
Genotype
Urology
Nerve Tissue Proteins
Locus (genetics)
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
03 medical and health sciences
Age
Internal medicine
Genetic variation
medicine
Genetic predisposition
Humans
cancer
Radiology
Nuclear Medicine and imaging
Aged
Neoplasm Staging
Bladder cancer
business.industry
medicine.disease
Urinary Bladder Neoplasms
Non-muscle-invasive bladder
Surgery
Neoplasm Grading
Carrier Proteins
business
Imputation (genetics)
GENETIC-VARIATIONS
Zdroj: European Urology Oncology, 2, 4, pp. 381-389
European Urology Oncology, 2, 381-389
European Urology Oncology, 2(4), 381-389. Elsevier
ISSN: 2588-9311
Popis: Background: Non-muscle-invasive bladder cancer (NMIBC) causes a considerable health burden due to the high recurrence and progression rates. Past studies have identified multiple candidate loci associated with NMIBC prognosis, albeit lacking validation. Moreover, scarce reports exist on genetic susceptibility to independent prognostic predictors of NMIBC, such as stage or grade.Objective: To investigate genetic associations with NMIBC tumour and patient characteristics at the time of diagnosis.Design, setting, and participants: A sample of 653 NMIBC cases comes from the Bladder Cancer Prognosis Programme. Replication of the significant findings was conducted in the Nijmegen Bladder Cancer Study cohort (N = 1470).Outcome measurements and statistical analysis: A genome-wide association study (GWAS) was carried out for outcomes of tumour size (as a continuous variable in centimetres), stage (Tis and T1 vs Ta), grade (G3 vs G2 and G1), and age (as continuous [years] and dichotomous [70.2 yr as a cut-off] variables).Results and limitations: Significant (p Conclusions: Our study suggests that rs180940944 (NBEA) is associated with an increased NMIBC tumour size at the time of diagnosis. Given study limitations, further eplication is essential to validate the finding.Patient summary: The current study reports on a genome-wide association study on non-muscle-invasive bladder cancer tumour and patient characteristics. We suggest that NBEA gene might be associated with increased tumour size at the time of diagnosis. The result must be replicated to establish validity.
Databáze: OpenAIRE
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