Genome-wide Association Study for Tumour Stage, Grade, Size, and Age at Diagnosis of Non-muscle-invasive Bladder Cancer
Autor: | Lambertus A. Kiemeney, Nadezda Lipunova, Anke Wesselius, Jean-Baptiste Cazier, Maurice P. Zeegers, Kar Keung Cheng, Richard T. Bryan, Frederik J. van Schooten, Tessel E. Galesloot |
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Přispěvatelé: | Promovendi NTM, Genetica & Celbiologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, Farmacologie en Toxicologie, RS: CAPHRI - R5 - Optimising Patient Care |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Oncology Stage PROGNOSIS Grade 030232 urology & nephrology Genome-wide association study SUSCEPTIBILITY VARIANTS 0302 clinical medicine Size IMPUTATION Aged 80 and over Age Factors Middle Aged Tumor Burden Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] 030220 oncology & carcinogenesis Cohort Female Adult medicine.medical_specialty CLINICAL-OUTCOMES Genotype Urology Nerve Tissue Proteins Locus (genetics) Single-nucleotide polymorphism Polymorphism Single Nucleotide 03 medical and health sciences Age Internal medicine Genetic variation medicine Genetic predisposition Humans cancer Radiology Nuclear Medicine and imaging Aged Neoplasm Staging Bladder cancer business.industry medicine.disease Urinary Bladder Neoplasms Non-muscle-invasive bladder Surgery Neoplasm Grading Carrier Proteins business Imputation (genetics) GENETIC-VARIATIONS |
Zdroj: | European Urology Oncology, 2, 4, pp. 381-389 European Urology Oncology, 2, 381-389 European Urology Oncology, 2(4), 381-389. Elsevier |
ISSN: | 2588-9311 |
Popis: | Background: Non-muscle-invasive bladder cancer (NMIBC) causes a considerable health burden due to the high recurrence and progression rates. Past studies have identified multiple candidate loci associated with NMIBC prognosis, albeit lacking validation. Moreover, scarce reports exist on genetic susceptibility to independent prognostic predictors of NMIBC, such as stage or grade.Objective: To investigate genetic associations with NMIBC tumour and patient characteristics at the time of diagnosis.Design, setting, and participants: A sample of 653 NMIBC cases comes from the Bladder Cancer Prognosis Programme. Replication of the significant findings was conducted in the Nijmegen Bladder Cancer Study cohort (N = 1470).Outcome measurements and statistical analysis: A genome-wide association study (GWAS) was carried out for outcomes of tumour size (as a continuous variable in centimetres), stage (Tis and T1 vs Ta), grade (G3 vs G2 and G1), and age (as continuous [years] and dichotomous [70.2 yr as a cut-off] variables).Results and limitations: Significant (p Conclusions: Our study suggests that rs180940944 (NBEA) is associated with an increased NMIBC tumour size at the time of diagnosis. Given study limitations, further eplication is essential to validate the finding.Patient summary: The current study reports on a genome-wide association study on non-muscle-invasive bladder cancer tumour and patient characteristics. We suggest that NBEA gene might be associated with increased tumour size at the time of diagnosis. The result must be replicated to establish validity. |
Databáze: | OpenAIRE |
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