Cardiovascular effects of the local injection of 5,7-dihydroxytryptamine into the nodose ganglia and nucleus tractus solitarius in awake freely moving rats

Autor: Nacera Merahi, Raul Laguzzi, C. M. Fattaccini, Anne Nosjean, Hakan S. Orer
Přispěvatelé: Neuropsychopharmacologie moléculaire, cellulaire et fonctionnelle, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), PERIGNON, Alain
Jazyk: angličtina
Rok vydání: 1991
Předmět:
Male
Baroreceptor
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Blood Pressure
MESH: Microinjections
MESH: Nerve Degeneration
MESH: Pressoreceptors
chemistry.chemical_compound
0302 clinical medicine
Heart Rate
MESH: Animals
MESH: Heart Rate
Medulla Oblongata
0303 health sciences
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Chemistry
General Neuroscience
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Electroencephalography
MESH: Blood Pressure
Hydroxyindoleacetic Acid
MESH: Electrooculography
MESH: Rats
Inbred Strains
MESH: 5
7-Dihydroxytryptamine
Electrodes
Implanted
Nodose Ganglion
medicine.drug
circulatory and respiratory physiology
Serotonin
medicine.medical_specialty
MESH: Hemodynamics
Microinjections
MESH: Rats
MESH: Reflex
5
7-Dihydroxytryptamine
Pressoreceptors
Baroreflex
Serotonergic
MESH: Hydroxyindoleacetic Acid
Injections
MESH: Electromyography
03 medical and health sciences
MESH: Nodose Ganglion
Internal medicine
MESH: Medulla Oblongata
Reflex
MESH: Electroencephalography
medicine
Animals
MESH: Injections
Molecular Biology
Microinjection
Phenylephrine
030304 developmental biology
Electromyography
Solitary nucleus
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Hemodynamics
Rats
Inbred Strains
MESH: Male
Rats
Electrooculography
Endocrinology
nervous system
Nerve Degeneration
MESH: Serotonin
MESH: Electrodes
Implanted
Neurology (clinical)
Neuroscience
[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Brain Research
Brain Research, 1991, 553 (1), pp.123-128. ⟨10.1016/0006-8993(91)90239-r⟩
Brain Research, Elsevier, 1991, 553 (1), pp.123-128. ⟨10.1016/0006-8993(91)90239-r⟩
ISSN: 0006-8993
Popis: International audience; The role of the nucleus tractus solitarius (NTS) serotonergic afferents in cardiovascular (CV) regulation is yet to be established. However, several findings suggest that in this nucleus the serotonergic endings coming from the nodose ganglia (NG) are involved in the control of blood pressure (BP). The purpose of the present study was to identify the CV effects of the destruction of this NG-NTS serotonergic pathway. For that, the BP, BP variability (BPV) and heart rate (HR) effects of the local microinjection of 5,7-dihydroxytryptamine (5,7-DHT), into the NG and NTS were investigated in awake freely moving rats. The local degeneration of serotonergic elements was associated with a significant decrease in the 5-HT and 5-hydroxyindole acetic acid levels within the NG and NTS in 5,7-DHT treated rats. In addition, the microinjection of the neurotoxin in both structures produced a transient and significant increase in BP. This effect was of greater amplitude and associated with an increase in BPV in NG lesioned rats. These results may indicate that the NG-NTS serotonergic pathway participates in the transfer of the messages arising from the aortic baroreceptors. However, the vagal component of the baroreflex assessed with the phenylephrine test was not significantly modified in NG lesioned animals as compared to controls. Consequently, if the present data suggest that the NG-NTS serotonergic pathway plays a depressor role in BP regulation, its involvement in the reflex CV responses triggered by the stimulation of the aortic baroreceptors has yet to be established.
Databáze: OpenAIRE
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