Maternal Serum Melatonin Increases During Pregnancy and Falls Immediately After Delivery Implicating the Placenta as a Major Source of Melatonin
| Autor: | Juliana K. Figaro, Helen F. Galley, Andrea Woolner, Bensita M.V. Thottakam, Haroon Ejaz |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty antioxidant Antioxidant Adolescent placenta Endocrinology Diabetes and Metabolism Metabolite medicine.medical_treatment melatonin Endogeny lcsh:Diseases of the endocrine glands. Clinical endocrinology Melatonin Young Adult 03 medical and health sciences chemistry.chemical_compound Endocrinology 0302 clinical medicine Internal medicine Placenta medicine Humans Prospective Studies Circadian rhythm Original Research Pregnancy lcsh:RC648-665 Cesarean Section business.industry melatonin (6-sulfatoxymelatonin) Delivery Obstetric medicine.disease Circadian Rhythm 030104 developmental biology medicine.anatomical_structure chemistry Gestation Female Pregnancy Trimesters pregnancy business Biomarkers hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Frontiers in Endocrinology, Vol 11 (2021) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | Melatonin is a neuroendocrine hormone which regulates circadian rhythm and is also an antioxidant. The role of melatonin in pregnancy is emerging. The enzymes needed for endogenous synthesis of melatonin have been identified in the placenta, although the contribution to circulating maternal melatonin in normal pregnancy is unclear. This work aimed to determine serum levels of melatonin and its major metabolite 6-hydroxymelatonin sulfate (6-OHMS) in normal pregnant women during each trimester of pregnancy, and immediately after delivery. Blood samples were obtained from a cohort of healthy pregnant women during each trimester of pregnancy (n = 26), from women scheduled for elective Cesarean section (CS) before and after delivery (n = 15), along with placental samples, and from healthy non-pregnant women as controls (n = 30). Melatonin and its major metabolite, 6-OHMS, were measured using enzyme immunoassay. Levels of serum melatonin were significantly higher during pregnancy than in non-pregnant women (P = 0.025) and increased throughout pregnancy (P < 0.0001). In women undergoing CS, serum melatonin decreased markedly 24 h after delivery (P = 0.0013). Similar results were seen for serum levels of 6-OHMS, and placental tissue 6-OHMS levels correlated with week of gestation at delivery (p = 0.018). In summary, maternal melatonin production is higher in pregnant than in non-pregnant women, increases significantly during pregnancy with highest levels in the third trimester, and decreases abruptly after delivery. These results suggest that the placenta is a major source of melatonin and supports a physiological role for melatonin in pregnancy. |
| Databáze: | OpenAIRE |
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