Increased efficiency of Lewis lung carcinoma chemotherapy with a macrophage stimulator--yeast carboxymethyl glucan

3)-beta-D-glucan (CMG)-a well-known macrophage stimulator. It was found that while cyclophosphamide showed 57% growth inhibition of the intramuscular tumor implants in comparison with the control group, its combined administration with CMG led to 75-90% inhibition. Similarly, increased inhibition of occurrence of lung metastases (up to 92-94%) was observed using the combined application of the two compounds. The stimulatory effect of CMG is not associated with the changed cellularity of peripheral blood, but is rather due to the obviously increased concentration of the intracellular inhibitor of cysteine proteases-stefin A and cystatin C in tumor tissue. -->

ISSN:	1567-5769
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8a57483c382efc1d62466ce8fed532 https://pubmed.ncbi.nlm.nih.gov/12095168
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi.dedup.....0f8a57483c382efc1d62466ce8fed532
Autor:	Olga N. Poteryaeva, Jozef Šandula, Tatyana A. Korolenko, Vasiliy I. Kaledin, Olga V. Falameeva, Grigorij Kogan, Tatyana G. Filatova, O. A. Levina, Svetlana Ya. Zhanaeva
Rok vydání:	2002
Předmět:	Male Lung Neoplasms beta-Glucans Cyclophosphamide medicine.medical_treatment Immunology Saccharomyces cerevisiae Pharmacology Cysteine Proteinase Inhibitors chemistry.chemical_compound Carcinoma Lewis Lung Mice Carcinoma medicine Leukocytes Immunology and Allergy Animals Glucans Glucan chemistry.chemical_classification Chemotherapy biology business.industry Macrophages Lewis lung carcinoma medicine.disease Xenograft Model Antitumor Assays Nitrogen mustard Mice Inbred C57BL Cysteine Endopeptidases chemistry Cystatin C biology.protein Mice Inbred CBA Drug Therapy Combination Growth inhibition business medicine.drug
Zdroj:	International immunopharmacology. 2(6)
ISSN:	1567-5769
Popis:	The efficiency of chemotherapy of Lewis lung carcinoma with cyclophosphamide was affected by administration of the water-soluble yeast polysaccharide derivative--carboxymethylated (1 --> 3)-beta-D-glucan (CMG)-a well-known macrophage stimulator. It was found that while cyclophosphamide showed 57% growth inhibition of the intramuscular tumor implants in comparison with the control group, its combined administration with CMG led to 75-90% inhibition. Similarly, increased inhibition of occurrence of lung metastases (up to 92-94%) was observed using the combined application of the two compounds. The stimulatory effect of CMG is not associated with the changed cellularity of peripheral blood, but is rather due to the obviously increased concentration of the intracellular inhibitor of cysteine proteases-stefin A and cystatin C in tumor tissue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8a57483c382efc1d62466ce8fed532 https://pubmed.ncbi.nlm.nih.gov/12095168 Zobrazit plný text záznamu Full Text from ScienceDirect