Painful and non-painful chemotherapy-induced peripheral neuropathy and quality of life in colorectal cancer survivors: Results from the population-based PROFILES registry

Autor: Cynthia S Bonhof, L.V. van de Poll-Franse, Hester R. Trompetter, Gerard Vreugdenhil, F. Mols
Přispěvatelé: Medical and Clinical Psychology
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Health-related quality of life
EUROPEAN-ORGANIZATION
Disease
0302 clinical medicine
Quality of life
Cancer Survivors
Surveys and Questionnaires
Medicine
ANXIETY
Registries
OXALIPLATIN
Netherlands
Chemotherapy-induced peripheral neuropathy
education.field_of_study
INSTRUMENT
Peripheral Nervous System Diseases
Middle Aged
humanities
PREVALENCE
Oncology
030220 oncology & carcinogenesis
Colonic Neoplasms
Anxiety
Female
Original Article
medicine.symptom
medicine.medical_specialty
Numbness
Pain medicine
Population
QUESTIONNAIRE
Pain
Antineoplastic Agents
BREAST
Hypesthesia
03 medical and health sciences
Internal medicine
Humans
Tingling
Paresthesia
education
Aged
business.industry
social sciences
medicine.disease
Colorectal cancer
Cancer registry
Peripheral neuropathy
Quality of Life
business
030217 neurology & neurosurgery
Zdroj: Supportive Care in Cancer, 28(12), 5933-5941. Springer
Supportive Care in Cancer
ISSN: 0941-4355
Popis: Purpose This study aims to (1) examine the prevalence of painful versus non-painful chemotherapy-induced peripheral neuropathy (CIPN) among long-term colorectal cancer (CRC) survivors, (2) identify sociodemographic, clinical, and psychological factors associated with painful and non-painful CIPN, and (3) examine the associations of painful CIPN with health-related quality of life (HRQoL) in comparison with non-painful CIPN, i.e., numbness/tingling. Methods All CRC survivors diagnosed between 2000 and 2009 as registered by the population-based Netherlands Cancer Registry (Eindhoven region) were eligible for participation. Chemotherapy-treated survivors (n = 477) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30). Results Painful CIPN was reported by 9% (n = 45) of survivors and non-painful CIPN was reported by 22% (n = 103). Time since diagnosis was related to painful CIPN, and time since diagnosis, a higher disease stage, osteoarthritis, and more anxiety symptoms were related to non-painful CIPN. Finally, survivors with painful CIPN reported a worse global quality of life and worse physical, role, cognitive, and social functioning compared to survivors with non-painful CIPN and those without any sensory CIPN. No differences were found between survivors with non-painful CIPN and those without sensory CIPN. Conclusions It seems that painful CIPN must be distinguished from non-painful CIPN, as only painful CIPN was related to a worse HRQoL. Future research is needed to examine whether painful CIPN must be distinguished from non-painful CIPN regarding predictors, mechanisms, and treatment.
Databáze: OpenAIRE
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