Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety
| Autor: | Niamh O’Halloran, Donald Courtney, Michael J. Kerin, Aoife Lowery |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment stromal-vascular fraction Adipose tissue skin-sparing mastectomy acellular dermal matrix Review lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer term-follow-up Tissue engineering Internal medicine medicine breast reconstruction acid-based scaffolds extracellular-matrix locoregional recurrence risk promote cancer progression business.industry Regeneration (biology) Cancer mastectomy adipose tissue engineering lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 030104 developmental biology quality-of-life 030220 oncology & carcinogenesis tissue engineering adipose-derived stem cells autologous fat transfer Stem cell business Breast reconstruction Mastectomy Biomedical engineering |
| Zdroj: | Breast Cancer: Basic and Clinical Research, Vol 11 (2017) Breast Cancer : Basic and Clinical Research |
| Popis: | Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer. |
| Databáze: | OpenAIRE |
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