Pretreatment risk stratification of feeding tube use in patients treated with intensity-modulated radiotherapy for head and neck cancer
| Autor: | Maziar Fahandej, Morikatsu Wada, Vincent Khoo, Hui K Gan, N. Anderson, James E. Jackson, Michael Poulsen, Michal Schneider, Daryl Lim Joon, Jennifer G. Smith, M. Rolfo |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Lymphadenopathy Risk Assessment 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Enteral Nutrition medicine Humans In patient Feeding tube Aged Retrospective Studies Aged 80 and over Univariate analysis business.industry Head and neck cancer Middle Aged medicine.disease Prognosis Radiation therapy Parenteral nutrition Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Lymphatic Metastasis Risk stratification Female Radiology Intensity modulated radiotherapy Radiotherapy Intensity-Modulated business Deglutition Disorders |
| Zdroj: | Headneck. 40(10) |
| ISSN: | 1097-0347 |
| Popis: | Background The purpose of this study was to establish a risk stratification model for feeding tube use in patients who undergo intensity-modulated radiotherapy (IMRT) for head and neck cancers. MethodsResultsOne hundred thirty-nine patients treated with definitive IMRT (+/- concurrent chemotherapy) for head and neck mucosal cancers were included in this study. Patients were recommended a prophylactic feeding tube and followed up by a dietician for at least 8 weeks postradiotherapy (post-RT). Potential prognostic factors were analyzed for risk and duration of feeding tube use for at least 25% of dietary requirements. Many variables had significant effects on risk and/or duration of feeding tube use in univariate analyses. Subsequent multivariable analysis showed that T classification 3 and level 2 lymphadenopathy were the best independent significant predictors of higher risk and duration of feeding tube use, respectively, in oral cavity, pharyngeal, and supraglottic primaries. ConclusionIn patients treated with definitive IMRT, T classification 3 and level 2 lymphadenopathy can potentially stratify patients into 4 risk groups for developing severe dysphagia requiring feeding tube use. |
| Databáze: | OpenAIRE |
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