Antimicrobial constituents of Gomphrena martiana and Gomphrena boliviana
| Autor: | Carlos A. Buschi, Alberto A. Viale, Alicia Beatriz Pomilio, Claudia Tomes |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Pharmacology
Gomphrena chemistry.chemical_classification Flavonoids Plants Medicinal biology Traditional medicine Plant Extracts Fungi Martiana Microbial Sensitivity Tests biology.organism_classification Antimicrobial Gram-Positive Bacteria Flavones Minimum inhibitory concentration chemistry.chemical_compound chemistry Drug Discovery Gram-Negative Bacteria Petroleum ether Isorhamnetin Antibacterial agent |
| Zdroj: | Journal of ethnopharmacology. 36(2) |
| ISSN: | 0378-8741 |
| Popis: | The antimicrobial activity of extracts and constituents of Gomphrena martiana and Gomphrena boliviana (Amaranthaceae) were determined in order to identify the compounds responsible for the folk-medicinal use of these plants. Each extract was evaluated against 20 microorganisms, including Gram-positive and Gram-negative bacteria, spore-forming Gram-positive bacteria, an acid-fast bacterium, a fungus and two yeasts. Fractionation of each petroleum ether (PE) extract yielded five 5,6,7-trisubstituted flavones that were separately tested showing high activity against M. phlei (minimum inhibitory concentration (MIC) 15, 20 and 75 micrograms/ml) approaching that of commercial bactericides. Other natural and synthetic flavonoids with diverse structures were also tested to define structure-activity relationships. Each EtOH extract was subsequently fractionated and monitored by bioassays leading to isorhamnetin 3-O-beta-robinobioside (MIC 50 micrograms/ml) in both instances. This glycoside is reported here for the first time in G. boliviana. |
| Databáze: | OpenAIRE |
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