| Autor: |
Lin Zhang, Jian Yu, Fangdong Zou, Zaneta Nikolovska-Coleska, Dongshi Chen, Shuai Tan, Peng Wang, Jingshan Tong |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22416716.v1 |
| Popis: |
Figure S1. Regorafenib and sorafenib did not affect Mcl-1 mRNA expression but induced GSK3β-dependent Mcl-1 degradation. A transfected quadruple mutant in 4 putative phosphorylation sites (S121A/E125A/S159A/T163A) of Mcl-1 was resistant to regorafenib-induced ubiquitination and degradation. Figure S2. Apoptosis induced by regorafenib or sorafenib was suppressed in HCT116 cells with Mcl-1 phosphorylation site mutant knock-in (Mcl-1-KI), inhibition of GSK3β, or knockout of BAX. Figure S3. Mcl-1 degradation and PUMA induction did not affect each other in regorafenib-induced apoptosis. Regorafenib-induced apoptosis in Mcl-1-KI cells could not be restored by the Bcl-2/Bcl-XL inhibitors ABT-737 or ABT-263. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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