Cord blood IgG and the risk of severe Plasmodium falciparum malaria in the first year of life
| Autor: | Loureen B. Oduor, Klara Sondén, Kevin Marsh, Fatuma Guleid, Greg Fegan, Irene Nkumama, Faith H. A. Osier, Anna Färnert, Mark Otiende, Linda M. Murungi, Dennis Odera, David T. Kangoye |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male 030231 tropical medicine Plasmodium falciparum Antibodies Protozoan Antigens Protozoan Article Cohort Studies 03 medical and health sciences Severe malaria 0302 clinical medicine Antigen Risk Factors parasitic diseases medicine Humans Malaria Falciparum Antibody ComputingMethodologies_COMPUTERGRAPHICS Respiratory Burst biology Infant Cord blood Odds ratio medicine.disease biology.organism_classification Fetal Blood Kenya Confidence interval 3. Good health Respiratory burst 030104 developmental biology Infectious Diseases Case-Control Studies Immunoglobulin G Immunology biology.protein Female Parasitology Merozoite Malaria |
| Zdroj: | International Journal for Parasitology |
| DOI: | 10.1016/j.ijpara.2016.09.005 |
| Popis: | Graphical abstract Highlights • Severe malaria episodes are rare during the first few months of life. • The rate of decay of cord blood IgG is inversely proportional to the starting concentration. • Antibody dependent respiratory burst mediated by cord IgG protects from severe malaria during the first 6 months of infancy. Young infants are less susceptible to severe episodes of malaria but the targets and mechanisms of protection are not clear. Cord blood antibodies may play an important role in mediating protection but many studies have examined their association with the outcome of infection or non-severe malaria. Here, we investigated whether cord blood IgG to Plasmodium falciparum merozoite antigens and antibody-mediated effector functions were associated with reduced odds of developing severe malaria at different time points during the first year of life. We conducted a case-control study of well-defined severe falciparum malaria nested within a longitudinal birth cohort of Kenyan children. We measured cord blood total IgG levels against five recombinant merozoite antigens and antibody function in the growth inhibition activity and neutrophil antibody-dependent respiratory burst assays. We also assessed the decay of maternal antibodies during the first 6 months of life. The mean antibody half-life range was 2.51 months (95% confidence interval (CI): 2.19–2.92) to 4.91 months (95% CI: 4.47–6.07). The rate of decline of maternal antibodies was inversely proportional to the starting concentration. The functional assay of antibody-dependent respiratory burst activity predicted significantly reduced odds of developing severe malaria during the first 6 months of life (Odds ratio (OR) 0.07, 95% CI: 0.007–0.74, P = 0.007). Identification of the targets of antibodies mediating antibody-dependent respiratory burst activity could contribute to the development of malaria vaccines that protect against severe episodes of malaria in early infancy. |
| Databáze: | OpenAIRE |
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