Biomimetic tissues on a chip for drug discovery
| Autor: | Hirokazu Kaji, Ali Khademhosseini, Matthew J. Hancock, Helen Harrington, Amir M. Ghaemmaghami |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Biomimetic materials Tissue Engineering Computer science Drug discovery Extramural Biocompatible Materials Nanotechnology Microfluidic Analytical Techniques Biocompatible material Models Biological Article ComputingMethodologies_PATTERNRECOGNITION Tissue engineering Biomimetic Materials Biomimetics Drug Discovery Animals Humans Microtechnology |
| Zdroj: | Drug Discovery Today. 17:173-181 |
| ISSN: | 1359-6446 |
| Popis: | Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development. |
| Databáze: | OpenAIRE |
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