| Autor: |
Josep M. Llovet, Scott L. Friedman, Myron Schwartz, Vincenzo Mazzaferro, Jordi Bruix, Stephen C. Ward, Swan Thung, Jordi Barretina, Hung-Wen Tsai, Philippa Newell, Beatriz Minguez, Augusto Villanueva, Yujin Hoshida, Sara Toffanin, Laia Cabellos, Radoslav Savic, Clara Alsinet, Anja Lachenmayer |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22444386.v1 |
| Popis: |
PDF file, 10.8MB, Supplementary Table 1: Clinical characteristics of human hepatocellular carcinoma samples. Supplementary Table 2: Clinical Characteristics of 5 public HCC datasets. Supplementary Table 3: Wnt-pathway mRNA list: 210 Wnt-related genes from the literature. Supplementary Table 4: Wnt-pathway miRNA list: 49 Wnt-related miRNAs from the literature. Supplementary Table 5: Significantly differentially expressed Wnt-related genes in CTNNB1- and Wnt-TGF_-class samples of the training set. Supplementary Table 6: Summary of dysregulated CTNNB1- and Wnt-TGF_-Wnt-genes according to their cellular localization and their known or suspected function. Supplementary Table 7: Expression of known liver-related Wnt-target-genes. Supplementary Table 8: Correlation of Wnt-related transcription factors to Wnt-target-genes in the training set. Supplementary Table 9: Frequency _catenin IHC positive samples and CTNNB1 mutations Wnt-related and non-Wnt-related subclasses of HCC in the in training (T) and validation (V) sets. Supplementary Table 10: Differentially expressed Wnt-related-miRNAs in 89 HCC samples of the training set. Supplementary Table 11: Enrichment of samples identified by CTNNB1-, Wnt-TGF__ WntGenes- and CTNNB1-mutation-signature in CTNNB1 and Wnt-TGF_ subclasses in 5 independent datasets (Fisher's Exact Test). Supplementary Table 12: 21 Liver Cancer cell lines analyzed by GSEA for gene expression profiles similar to either CTNNB1 or Wnt-TGF_ class. Supplementary Figure 1: Differential Expression of Wnt-pathway mRNAs in the CTNNB1- and Wnt-TGF Beta-classes in the training set. Supplementary Figure 2: Differential Expression of Wnt-pathway-miRNAs in the CTNNB1- and Wnt-TGF Beta-classes in the training set. Supplementary Figure 3: Validation of CTNNB1- and Wnt-TGF Beta-specific Wnt-related mRNA profiles and mutation-status in 5 public HCC datasets. Supplementary Figure 4: Validation of the mutation signature in an independent cohort of HCC. Supplementary Figure 5: Correlation of gene expression data from 21 different liver cancer cell lines with CTNNB1 and Wnt-TGF Beta class signatures by GSEA. Supplementary Figure 6: Baseline luciferase levels in Wnt reporter liver cancer cells stably transduced with TCF/LEF luciferase reporter. Supplementary Figure 7: Sorafenib decreases beta-catenin protein levels in 4 liver cancer cell lines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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