Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats
| Autor: | Thomas Kiy, Satohiro Tanaka, Andrea W. Wong, René Blum, Ashley Roberts |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Salmonella typhimurium medicine.medical_specialty Docosahexaenoic Acids Biology Weight Gain Toxicology medicine.disease_cause Chinese hamster Rats Sprague-Dawley Cricetinae medicine Animals Food science Toxicity Tests Chronic Cell Proliferation Chromosome Aberrations chemistry.chemical_classification Dose-Response Relationship Drug Mutagenicity Tests Sodium fungi Eukaryota food and beverages Organ Size General Medicine Fibroblasts Fish oil biology.organism_classification Rats Dose–response relationship Liver Biochemistry chemistry Docosahexaenoic acid Mutation Toxicity Potassium Female lipids (amino acids peptides and proteins) Histopathology Oils Genotoxicity Polyunsaturated fatty acid |
| Zdroj: | Regulatory Toxicology and Pharmacology. 49:271-284 |
| ISSN: | 0273-2300 |
| DOI: | 10.1016/j.yrtph.2007.08.005 |
| Popis: | Polyunsaturated fatty acids, including docosahexaenoic acid (DHA), are natural constituents of the human diet. DHA-algal oil is produced through the use of the non-toxigenic and non-pathogenic marine protist, Ulkenia sp. The safety of DHA-algal oil was assessed in a subchronic toxicity study and in genotoxicity studies. In a 90-day study, rats were orally administered water or DHA-algal oil at concentrations of 0, 500, 1000, and 2000 mg/kg in combination with 2000, 1500, 1000 or 0 mg/kg DHA-containing fish oil, respectively. Additional animals were administered water, 2000 mg/kg DHA-algal oil, or 2000 mg/kg fish oil for 90 days, followed by a 4-week recovery phase. No treatment-related effects were observed in clinical observations, food and water consumption, mortality, gross pathology, and histopathology. Increased body weights and liver weights in oil-treated groups were attributed to the large lipid load and were not regarded as toxicologically significant. Furthermore, no treatment-related differences in the measured parameters between the DHA-algal oil and fish oil groups were detected. In genotoxicity experiments, DHA-algal oil exerted no mutagenic activity in various bacterial strains, nor did it induce chromosomal aberrations in Chinese hamster fibroblast cells. These results support the safety of DHA-algal oil as a dietary source of DHA. |
| Databáze: | OpenAIRE |
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