Effect of piperine on the bioavailability and pharmacokinetics of rosmarinic acid in rat plasma using UPLC-MS/MS
| Autor: | Yin-Jun Ye, Jun-Hui Yang, Bao-Chang Cai, Hua-Shan Guo, Kun-Jun Mao, Ping Huang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Polyunsaturated Alkamides Health Toxicology and Mutagenesis Glucuronidation Cmax Administration Oral Pharmacology Toxicology Biochemistry Depsides 03 medical and health sciences chemistry.chemical_compound Plasma 0302 clinical medicine Alkaloids Pharmacokinetics Piperidines Oral administration Animals Cytochrome P-450 Enzyme Inhibitors Drug Interactions Benzodioxoles Rosmarinic acid General Medicine Bioavailability Rats 030104 developmental biology chemistry Cinnamates Piperine Glucuronide 030217 neurology & neurosurgery |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 48(2) |
| ISSN: | 1366-5928 |
| Popis: | 1. The purpose of the present study was to investigate the effect of piperine (PP) on the pharmacokinetics of rosmarinic acid (RA) in rat plasma and to determine whether PP could enhance the oral bioavailability of RA via inhibition of its glucuronidation.2. The pharmacokinetic profiles of RA between oral administration of RA (50 mg/kg) alone and in combination with different oral dose PP (20, 40, 60, and 80 mg/kg) to rats were investigated via a validated UPLC/MS/MS method.3. The AUC and Cmax of RA were significantly increased in combination with different dose PP dose dependently, especially in the presence of 60 and 80 mg/kg PP (p |
| Databáze: | OpenAIRE |
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