Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test
| Autor: | V. Mersch-Sundermann, Klaus Kümmerer, Ali Al-Ahmad |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Ofloxacin
Antibiotics Metabolite Toxizität SOS chromotest Bioassay RISK ASSESSMENT hospital bacteria Inhibition hospital effluents EXCRETION General Medicine Pollution PSEUDOMONAS-PUTIDA BACTERIUM GROWTH HEALTH Cell Division Human Environmental Engineering environmental risk assessment Microbial Sensitivity Tests SUBSTANCES Microbiology MUNICIPAL SEWAGE Inhibitory Concentration 50 elimination biodegradability Pseudomonas Humans REACh sewage effects SOS Response Genetics ENVIRONMENT Bacteria Pseudomonas putida EFFLUENTS Public Health Environmental and Occupational Health Pathogenic bacteria Oxygen IT SOS-Chromotest chemistry UNIT adverse effects ANTIBIOTIC Test ADVERSE Health Toxicology and Mutagenesis environmental risk medicine.disease_cause Waste Disposal Fluid METABOLITES environmental chemistry.chemical_compound Ciprofloxacin AQUATIC ENVIRONMENTS Abbaubarkeit risk Sewage effect UNITS drug COMPOUND HUMANS Anti-Bacterial Agents Chemistry Biodegradation Environmental OECD aquatic environment ORGANISMS concentration hazard medicine.drug_class Biology Toxicity Tests Control medicine DRUGS Environmental Chemistry wastewater Mutagenicity Tests Closed Bottle Test genotoxicity toxicity aquatic SOS General Chemistry biology.organism_classification Risk-Assessment METRONIDAZOLE hospital effluent effluent Xenobiotic Genotoxicity TOXICITIES Waste disposal |
| Zdroj: | Kümmerer, K, Al-Ahmad, A & Mersch-Sundermann, V 2000, ' Biodegradability of some antibiotics, elimination of their genotoxicity and affection of waste water bacteria in a simple test. ' Chemosphere, vol 40, no. 7, pp. 701-710 . DOI: 10.1016/S0045-6535(99)00439-7 Kümmerer, K, Al-Ahmad, A & Mersch-Sundermann, V 2000, ' Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test ', Chemosphere, vol. 40, no. 7, pp. 701-710 . https://doi.org/10.1016/S0045-6535(99)00439-7 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/s0045-6535(99)00439-7 |
| Popis: | Most antibiotics and their metabolites are excreted by humans after administration and therefore reach the municipal sewage with the excretions. Only little is known about their biodegradability in aquatic environments. It was recognised that genotoxic substances may represent a health hazard to humans but also may affect organisms in the environment. Therefore, the biodegradability of some clinically important antibiotic drugs (ciprofloxacin, ofloxacin, metronidazole) and hereby the elimination of their genotoxicity was investigated as the first step of an environmental risk assessment using the Closed Bottle test (CBT) (OECD 301 D) and the SOS chromotest. Additionally, to assess toxicity of the antibiotics tested against aquatic bacteria (i) a growth inhibition test (GIT) with Pseudomonas putida was conducted, (ii) a toxicity control was used in the CBT and (iii) the colony forming units (CFUs) were monitored in the test vessels. Worst case concentrations of the antibiotics in hospital effluents were estimated and compared with minimum inhibitory concentrations for susceptible pathogenic bacteria and with the genotoxic potency in the SOS chromotest. Both the concentrations calculated for hospital effluents and the adverse effects in bacteria were in the same order of magnitude. None of the test compounds were biodegraded. The genotoxicity was not eliminated. (C) 2000 Elsevier Science Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect