Long-Term Follow-Up of Patients Treated With Paclitaxel/Carboplatin-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer: Sequential Phase II Trials of the Minnie Pearl Cancer Research Network
| Autor: | J. R. Gray, F. Anthony Greco, John D. Hainsworth, L A Kalman, Jeremy K. Hon, Lisa H. Morrissey |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Oncology Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty Lung Neoplasms Time Factors Paclitaxel medicine.medical_treatment Vinblastine Vinorelbine Deoxycytidine Drug Administration Schedule Carboplatin chemistry.chemical_compound Actuarial Analysis Carcinoma Non-Small-Cell Lung Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Lung cancer Survival rate Survival analysis Aged Aged 80 and over Chemotherapy business.industry Middle Aged medicine.disease Antineoplastic Agents Phytogenic Survival Analysis Gemcitabine Surgery Treatment Outcome chemistry Female business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 20:2937-2942 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2002.10.071 |
| Popis: | PURPOSE: To provide long-term follow-up on the survival of patients with advanced non–small-cell lung cancer treated with paclitaxel/carboplatin-based regimens in a multicenter, community-based setting. PATIENTS AND METHODS: Between March 1995 and April 1998, 321 patients with newly diagnosed stage IIIB or IV non–small-cell lung cancer were treated on sequential phase II trials with the following combination regimens: paclitaxel/carboplatin, paclitaxel/carboplatin/gemcitabine, and paclitaxel/carboplatin/vinorelbine. Details of these three regimens and patient populations have been previously reported. Responding and stable patients continued treatment until tumor progression or for a recommended six treatment courses. RESULTS: After a median follow-up of 58 months (minimum follow-up, 40 months), the median survival for the entire group of patients was 8.6 months, with actual 1-, 2-, and 3-year survival rates of 40%, 19%, and 7%, respectively. The actuarial 4-year survival rate for the entire group was 4%. No statistically significant differences in survival were seen among the three regimens. Administration of all three regimens was feasible in a community-based setting; however, myelosuppression and hospitalizations for treatment of neutropenia/fever were more frequent with the three-drug regimens. CONCLUSION: Paclitaxel/carboplatin-based regimens, in addition to prolonging median survival and improving 1-year survival, result in substantial improvements in the 2-year survival of patients with advanced non–small-cell lung cancer when compared retrospectively with supportive care or traditional cisplatin-based regimens. In these sequential phase II trials, we did not demonstrate any advantages of three-drug regimens when compared with paclitaxel/carboplatin. Because few patients remain alive after 4 years with any of these chemotherapy regimens, future treatment improvements will require the introduction of novel agents. |
| Databáze: | OpenAIRE |
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