Highly polymorphic apolipoprotein A-IV locus in the baboon
| Autor: | B Sepehrnia, Kamboh Mi, J L VandeBerg, Robert E. Ferrell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
Male
Very low-density lipoprotein Apolipoprotein B QD415-436 Apolipoprotein A-IV Biochemistry Endocrinology Gene Frequency biology.animal Genetic variation Animals Allele Allele frequency Alleles Apolipoproteins A Genetics Polymorphism Genetic biology Genetic Variation Cell Biology Molecular biology Pedigree Phenotype biology.protein Female lipids (amino acids peptides and proteins) Chylomicron Baboon Papio |
| Zdroj: | Journal of Lipid Research, Vol 31, Iss 1, Pp 131-135 (1990) |
| ISSN: | 0022-2275 |
| Popis: | Apolipoprotein A-IV is found in mesenteric lymph chylomicrons, very low density lipoprotein particles, high density lipoprotein particles, and in the lipoprotein-free fraction of plasma. Apolipoprotein A-IV is polymorphic in a variety of species including human, dog, and horse. Efforts to estimate the impact of apolipoprotein A-IV structural variation on quantitative lipid levels in humans have been limited by the low frequency of the less common alleles. In the baboon, Papio hamadryas anubis, we have found apolipoprotein A-IV to be highly variable at the protein level with five alleles appearing at polymorphic frequency. We have confirmed the autosomal codominant inheritance of these five alleles in pedigreed baboons. The baboon has been shown to be a suitable animal model for the study of atherosclerosis, and the existence of a common, multi-allele apolipoprotein A-IV polymorphism in the baboon may be useful in elucidating the role of apolipoprotein A-IV in lipid metabolism. |
| Databáze: | OpenAIRE |
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