Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles
| Autor: | Caroline Casagrande Sipoli, Lucimara Gaziola de la Torre, Amanda da Costa e Silva de Noronha Pessoa |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Diffusion Microfluidics Biomedical Engineering Mixing (process engineering) Nanoparticle Bioengineering Nanotechnology Context (language use) 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Chitosan chemistry.chemical_compound Adenosine Triphosphate Nanoparticle Production General Chemistry Equipment Design Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Homogeneous Nanoparticles 0210 nano-technology |
| Zdroj: | Lab on a chip. 17(13) |
| ISSN: | 1473-0189 |
| Popis: | Chitosan (CHI) nanoparticles present promising applications in pharmaceutical and biomedical fields, including drug and gene delivery. Among different approaches, microfluidics emerges as a resourceful tool for nanoparticle production in low-cost, reproducible processes with predictable fluid dynamics. However, microfluidic-assisted synthesis of CHI nanoparticles has not been widely explored in the literature. In this context, we systematically investigated different process parameters that influence the synthesis of CHI/ATP nanoparticles. We highlight the effects and limitations of diffusion and distinct mixing patterns developed through the microchannels on the final physicochemical characteristics of CHI/ATP nanoparticles produced. To address these hurdles, here we describe a simple, feasible, and reproducible method for the production of CHI/ATP nanoparticles. This strategy enables the development of a continuous and homogeneous production process for CHI nanoparticles to be applied in the most varied fields of research. |
| Databáze: | OpenAIRE |
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