Dispersion of ventricular repolarization in dilated cardiomyopathy
| Autor: | Annie Robert, Christian Brohet, Robert Fesler, C. Derwael, M Zaidi |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Heart disease Cardiomyopathy QT interval Electrocardiography QRS complex Heart Conduction System Internal medicine medicine Humans cardiovascular diseases Risk factor Retrospective Studies medicine.diagnostic_test business.industry Dilated cardiomyopathy Middle Aged medicine.disease cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Complication |
| Zdroj: | European Heart Journal. 18:1129-1134 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/oxfordjournals.eurheartj.a015408 |
| Popis: | OBJECTIVE: Increased dispersion of ventricular repolarization has been shown to be a marker for increased risk of ventricular tachyarrhythmias in various cardiac disorders. The present study is aimed at comparing the values of four dispersion indices in four clinical groups: normal subjects (n = 23), patients with intraventricular conduction defects (QRS > 0.12 s) without underlying cardiac disease (n = 30), patients with dilated cardiomyopathy (n = 36), and patients with both dilated cardiomyopathy and ventricular conduction defects (n = 18). METHODS: On an averaged cycle from a 10 s record of 15 simultaneous leads (12-lead ECG and XYZ leads), and after interactive editing, four intervals were computed: JTapex, JTend, QTapex and QTend. For each interval, the dispersion is defined as the difference between the maximal and minimal values across the 15 leads. RESULTS: The mean values of all four dispersion indices were significantly smaller in the normal group than in the three other groups (P < 0.001). Among patients with dilated cardiomyopathy, those with intraventricular conduction defects had significantly higher dispersion values than those without, even disregarding the QRS duration (P < 0.01). Thus, patients with both dilated cardiomyopathy and ventricular conduction defects have larger dispersion values than patients with ventricular conduction defects alone (P < 0.01) and than those with dilated cardiomyopathy without intraventricular conduction defects. CONCLUSION: Dispersion of ventricular repolarization is increased in patients with dilated cardiomyopathy, especially in those with ventricular conduction defects, suggesting that they are at higher risk of arrhythmic events. |
| Databáze: | OpenAIRE |
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