Tumor necrosis serum induces a serologically distinct population of NK cells
| Autor: | G F Hämmerling, M K Hoffmann, U Hämmerling, M Chun, V Pasanen |
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| Rok vydání: | 1979 |
| Předmět: |
Cytotoxicity
Immunologic Immunology Mice Nude Mice Inbred Strains Biology CD49b Mice Interleukin 21 NK-92 Animals Immunology and Allergy Antigen-presenting cell Antilymphocyte Serum Lymphokine-activated killer cell Janus kinase 3 Articles Neoplasms Experimental Molecular biology Immunity Innate Killer Cells Natural Blood Antigens Surface Interleukin 12 Myeloid-derived Suppressor Cell Interferons Spleen |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.150.3.426 |
| Popis: | Murine spleen cells generate nonspecific cytotoxic cells, referred to as natural killer (NK) cells, within 4 d of incubation in Mishell-Dutton cultures. This NK cell type does not arise in cultures of BALB/c.nu spleen cells or in cultures of T-cell depleted C57BL/6 spleen cells, indicating that its activation depends on T cells. Another type of NK cells is induced by tumor necrosis serum in murine spleen-cell cultures. It arises within 24 h and its activation does not depend on T cells. This cell type (and its precursor) expresses the recently discovered cell-surface marker Qa5 (controlled by the Q region of chromosome 17) that distinguishes this NK cell from the NK cell that depends for its activation on thymic function. Qa5+ NK cells are also induced by interferon. |
| Databáze: | OpenAIRE |
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