Temporal summation of the nociceptive withdrawal reflex involves deactivation of posterior cingulate cortex
| Autor: | Emanuele Siravo, Mariano Serrao, R De Icco, Claudio Colonnese, Maria Grazia Anastasio, Antonio Ferretti, Francesco Pierelli, Michelangelo Bartolo, Luigi Pavone, Giovanni Grillea, Armando Perrotta, Piero Chiacchiaretta, Giorgio Sandrini |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Nociception 0301 basic medicine Pain Withdrawal reflex Summation Gyrus Cinguli Young Adult 03 medical and health sciences 0302 clinical medicine Nociceptive Reflex Cortex (anatomy) Reflex medicine Humans Anterior cingulate cortex Pain Measurement Secondary somatosensory cortex Magnetic Resonance Imaging 030104 developmental biology Anesthesiology and Pain Medicine medicine.anatomical_structure Posterior cingulate adult female gyrus cinguli humans magnetic resonance imaging male nociception pain pain measurement reflex young adult Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Pain. 21:289-301 |
| ISSN: | 1090-3801 |
| Popis: | Background Temporal summation of pain sensation is pivotal both in physiological and pathological nociception. In humans, it develops in parallel with temporal summation of the nociceptive withdrawal reflex (NWR) of the lower limb, an objective representation of the temporal processing of nociceptive signals into the spinal cord. Methods To study the contribution of cortical and subcortical structures in temporal summation of pain reflex responses, we compared the fMRI signal changes related to the temporal summation threshold (TST) of the NWR with that related to the single NWR response. We studied 17 healthy subjects using a stimulation paradigm previously determined to evoke both the TST of the NWR (SUMM) and the NWR single response (SING). Results We found a significant activation in left (contralateral) primary somatosensory cortex (SI), bilateral secondary somatosensory cortex (SII), bilateral insula, anterior cingulate cortex (ACC) and bilateral thalamus during both SUMM and SING conditions. The SUMM versus SING contrast revealed a significant deactivation in the posterior cingulate cortex (PCC) and bilateral middle occipital gyrus in SUMM when compared to SING condition. Conclusions Our data support the hypothesis that temporal summation of nociceptive reflex responses is driven through a switch between activation and deactivation of a specific set of brain areas linked to the default mode network. This behaviour could be explained in view of the relevance of the pain processing induced by temporal summation, recognized as a more significant potential damaging condition with respect to a single, isolated, painful stimulation of comparable pain intensity. Significance The study demonstrated that TST of the NWR involves a selective deactivation of PCC. |
| Databáze: | OpenAIRE |
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