Double-Contrast Enhanced MR Imaging of Myocardial Infarction in the Pig
| Autor: | Anders Waldenström, Anders Ericsson, M. Wikström, H. J. Martinussen, Gerhard Wikström, Anders Hemmingsson |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Gadolinium DTPA
Male Coronary artery occlusion Swine Myocardial Infarction Contrast Media Infarction 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Occlusion Organometallic Compounds medicine Animals Radiology Nuclear Medicine and imaging cardiovascular diseases Myocardial infarction Proton density Radiological and Ultrasound Technology business.industry Myocardium General Medicine Pentetic Acid medicine.disease Magnetic Resonance Imaging Mr imaging Contrast medium medicine.anatomical_structure 030220 oncology & carcinogenesis cardiovascular system Female Nuclear medicine business Artery |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.1080/02841859309173239 |
| Popis: | Myocardial infarction was induced by ligating a diagonal branch of the left anterior descending artery in 18 pigs. All pigs were sacrificed 6 h after the occlusion. Dysprosium diethylenetriaminepentaacetic acid bismethylamide (Dy-DTPA-BMA, 1.0 mmol/kg) was administered i.v. to 6 pigs, starting 3 min before sacrifice (injection time approximately 1 min). In a second group of 6 pigs, a double-contrast technique was used, consisting of an i.v. injection of gadolinium-DTPA-BMA (0.4 mmol/kg) 2 h before sacrifice, followed by an i.v. injection of Dy-DTPA-BMA (1.0 mmol/kg) 3 min before sacrifice. Six additional pigs, subjected to 6 h of coronary artery occlusion without administration of contrast medium, served as controls. The hearts were excised and imaged with MR. In the control animals, the infarctions demonstrated an increased signal intensity in the proton density- and T2-weighted images. Administration of Dy-DTPA-BMA primarily improved infarct visualization in the proton density- and T2-weighted images, due to reduction of signal intensity in nonischemic myocardium. The double-contrast technique further improved infarct visualization in all sequences. |
| Databáze: | OpenAIRE |
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