Comprehensive therapeutic outcomes of frontline imatinib mesylate in newly diagnosed chronic phase chronic myeloid leukemia patients in Korea: feasibility assessment of current ELN recommendation
| Autor: | Soo-Hyun Kim, Hyun Gyung Goh, Dong-Wook Kim, Dongho Kim, Eun-Jung Jang, Soo Young Choi, Sa-Hee Park |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Myeloid Time Factors Adolescent Antineoplastic Agents Single Center Piperazines Medication Adherence Young Adult Internal medicine medicine Humans Clinical significance Protein Kinase Inhibitors Survival analysis Aged business.industry Imatinib Hematology Middle Aged medicine.disease Survival Analysis Leukemia medicine.anatomical_structure Imatinib mesylate Pyrimidines Treatment Outcome Molecular Response Benzamides Leukemia Myeloid Chronic-Phase Physical therapy Imatinib Mesylate Female business medicine.drug |
| Zdroj: | International journal of hematology. 96(1) |
| ISSN: | 1865-3774 |
| Popis: | Optimal responses during imatinib therapy are commonly defined following the European LeukemiaNet (ELN) recommendations. Achievements of these optimal responses have not, however, been comprehensively tested as response-related prognostic factors using single center data sets. We evaluated the parameters using long-term (median 63 months) outcomes from 363 chronic phase chronic myeloid leukemia patients treated with imatinib as frontline therapy at our center. Intention-to-treat analysis showed comparable rates of complete cytogenetic response (86 %), major molecular response (MMR, 54 %), and complete molecular response (MR(4.5), 8 %). Estimated overall survival, progression-free survival, and event-free survival at 7 years were 94, 88 and 84 %, respectively. Achievement of recommended optimal response at 6 months (major cytogenetic response) and 12 months (complete cytogenetic response) yielded significantly better overall, progression-free, and event-free survival. However, achievement of recommended optimal response at 18 months (MMR) provided marginal benefit only in event-free survival. Most ELN criteria were predictive of long-term outcomes, with the exception of the clinical significance of achieving MMR at 18 months. Treatment adherence in the early treatment period was one of the important independent predictors of favorable long-term outcome. Durable cytogenetic and molecular responses were maintained in a majority of patients treated with optimal dose intensity. |
| Databáze: | OpenAIRE |
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