Enzymatic C4‐Epimerization of UDP‐Glucuronic Acid: Precisely Steered Rotation of a Transient 4‐Keto Intermediate for an Inverted Reaction without Decarboxylation

Autor:	Oriol Esquivias, Annika Borg, Carme Rovira, Joan Coines, Bernd Nidetzky
Rok vydání:	2022
Předmět:	General Chemistry Catalysis
Zdroj:	Angewandte Chemie International Edition. 62
ISSN:	1521-3773 1433-7851
DOI:	10.1002/anie.202211937
Popis:	UDP-glucuronic acid (UDP-GlcA) 4-epimerase illustrates an important problem regarding enzyme catalysis: balancing conformational flexibility with precise positioning. The enzyme coordinates the C4-oxidation of the substrate by NAD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6948ddbcafb1f28cae50e2926fb0dc https://doi.org/10.1002/anie.202211937 Zobrazit plný text záznamu Plný text