Associations between baseline biomarkers and lung function in HIV-positive individuals
| Autor: | Ken M. Kunisaki, Gary Collins, David M MacDonald, Eliana Loiza, Chris H. Wendt, Vasileios Papastamopoulos, Alexander D Zanotto, Marcin Czarnecki, Robin Wood, Jason V. Baker, Daniel E. Nixon |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Spirometry Adult Lung Diseases Male medicine.medical_specialty Vital capacity Bilirubin Immunology HIV Infections Systemic inflammation Gastroenterology Article 03 medical and health sciences FEV1/FVC ratio chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Immunology and Allergy Humans 030212 general & internal medicine Serum amyloid A Longitudinal Studies Lung medicine.diagnostic_test business.industry respiratory system Intercellular adhesion molecule respiratory tract diseases Respiratory Function Tests 030104 developmental biology Infectious Diseases chemistry Disease Progression Biomarker (medicine) Female medicine.symptom business Biomarkers |
| Zdroj: | AIDS (London, England). 33(4) |
| ISSN: | 1473-5571 |
| Popis: | Objective The aim of this study was to analyse the association of baseline biomarker data with cross-sectional lung function and subsequent decline in lung function in HIV-positive persons. Design Lung function was modelled in all START pulmonary substudy participants who had baseline biomarker data and good-quality spirometry. In longitudinal analyses, we restricted to those participants with at least one good-quality follow-up spirometry test. Methods We performed linear regression of baseline forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC and their longitudinal slopes on log2-transformed baseline biomarkers with adjustment for age, sex, race, region, smoking status, baseline CD4+ T-cell counts and baseline HIV-RNA. Biomarkers included D-dimer, high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-27, serum amyloid A, soluble intercellular adhesion molecule (sICAM)-1, soluble vascular cell adhesion molecule (sVCAM)-1, albumin and total bilirubin. Results Among 903 included participants, baseline median age was 36 years, CD4+ cell count was 647 cells/μl, and 28.5% were current smokers. In adjusted analyses, elevated markers of systemic inflammation (hsCRP, IL-6 and serum amyloid A) were associated with lower baseline FEV1 and FVC. Elevated D-dimer and IL-6 were associated with worse airflow obstruction (lower FEV1/FVC). Despite these cross-sectional associations at baseline, no associations were found between baseline biomarkers and subsequent longitudinal lung function decline over a median follow-up time of 3.9 years (3293 spirometry-years of follow-up). Conclusion Commonly available biomarkers, in particular markers of systemic inflammation, are associated with worse cross-sectional lung function, but do not associate with subsequent lung function decline among HIV-positive persons with early HIV infection and baseline CD4 T-cell counts more than 500 cells/μl. |
| Databáze: | OpenAIRE |
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