Comparison of medium-dose losartan/hydrochlorothiazide and maximal-dose angiotensin II receptor blockers in the treatment of Japanese patients with uncontrolled hypertension: the Kobe-CONNECT Study
| Autor: | Hidemi Nonaka, Masakuni Suematsu, Yoshimichi Inoue, Ryuji Toh, Yasuo Kitagawa, Noriaki Emoto, Ken-ichi Hirata, Tatsuro Ishida, Kunihiro Nishimura, Takashi Miki |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Physiology medicine.drug_class Losartan/hydrochlorothiazide Diastole Blood Pressure Pharmacology Drug Administration Schedule Losartan Excretion Angiotensin Receptor Antagonists Hydrochlorothiazide Asian People Japan Internal Medicine medicine Natriuretic peptide Humans Prospective Studies Diuretics Thiazide Antihypertensive Agents Aged Dose-Response Relationship Drug business.industry Middle Aged Circadian Rhythm Blood pressure Treatment Outcome Hypertension Drug Therapy Combination Female Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 35(11) |
| ISSN: | 1348-4214 |
| Popis: | The objective of this study is to examine the effects of thiazide diuretics, plus medium-dose losartan versus maximal-dose angiotensin II receptor blockers (ARBs) on blood pressure (BP) in Japanese patients with uncontrolled hypertension despite the use of medium-dose ARBs. Hypertensive patients in whom BP was inadequately controlled by treatment with medium-dose ARBs alone or with calcium-channel blockers were enrolled. Patients were randomly assigned to a fixed-dose combination of 50 mg per day losartan and 12.5 mg per day hydrochlorothiazide (HCTZ; n=98), or to a maximal dose of current ARBs (n=95). The reduction in office BP from baseline was significantly larger in the losartan/HCTZ group than in the maximal-dose ARB group (systolic BP -22.7±13.7 vs. -11.7±13.0 mm Hg, diastolic BP -9.6±10.9 vs. -4.5±11.0 mm Hg; P |
| Databáze: | OpenAIRE |
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