Role of mast cells in the pathogenesis of liver fibrosis in nonalcoholic fatty liver disease
| Autor: | Andrzej Zieliński, Agnieszka Wosiak, Piotr Brzeziński, Józef Kobos, Dariusz Szymański, Ewa A. Lewandowska, Janusz Strzelczyk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
obesity Pathology medicine.medical_specialty business.industry Liver fibrosis mast cells General Medicine nafld medicine.disease Pathology and Forensic Medicine Pathogenesis Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease Humans Medicine Mast (botany) business liver fibrosis |
| Zdroj: | Polish Journal of Pathology, Vol 71, Iss 1, Pp 38-45 (2020) |
| ISSN: | 1233-9687 |
| DOI: | 10.5114/pjp.2020.95414 |
| Popis: | Nonalcoholic fatty liver disease (NAFLD), a very common comorbidity of obesity, may progress from simple steatosis to nonalcoholic steatohepatitis and liver cirrhosis. The aim of this study was to determine whether mast cells (MCs) participate in the pathogenesis of liver fibrosis in patients with NAFLD. Liver specimens collected either from obese subjects or the control group were prepared for histological examination. The patients were divided into groups depending on inflammation and fibrosis grade, and the mean total number of mast cells/mm2 and those located only in portal areas/ fibrous septa or within lobules were calculated for each grade. Mast cells were detected by pina-cyanol erythrosinate staining. There was a strong positive correlation between the number of mast cells, especially those located within portal areas and fibrous septa, and the liver fibrosis grade (r = 0.736, p |
| Databáze: | OpenAIRE |
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