An oral controlled release system for amroxol hydrochloride containing a wax and a water insoluble polymer
| Autor: | Xing Tang, Wei Zhang, Na Chi, Yu Zhang, Ju Hong Guo |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Hot Temperature
Polymers Hydrochloride Stereochemistry Drug Compounding Administration Oral Excipient Pharmaceutical Science Dosage form Pellet Dosage Form Excipients Matrix (chemical analysis) chemistry.chemical_compound Drug Delivery Systems Drug Stability medicine Particle Size Cellulose Expectorants Wax Fatty Acids Temperature Water General Medicine Controlled release Ambroxol Solubility chemistry Delayed-Action Preparations Drug Design Waxes visual_art visual_art.visual_art_medium Glyceryl behenate Nuclear chemistry medicine.drug |
| Zdroj: | Pharmaceutical Development and Technology. :090812030738083-8 |
| ISSN: | 1097-9867 1083-7450 |
| Popis: | This study was carried out to develop and optimize oral sustained-release formulations for Ambroxol hydrochloride matrix pellets using a combination of wax and water-insoluble polymer, glyceryl behenate (Compritol 888 ATO) and Ethylcellulose (EC(7 FP)). It involved three factors: the content of Compritol 888 ATO (X(1)), EC(7 FP) (X(2)), and the matrix formation methods (X(3)), as independent variables. The drug release percentages at 1, 2 and 4 h were the target responses and were restricted to 15-45% (Y(1)), 45-80% (Y(2)) and 80-100% (Y(3)), respectively. The final blend formulation prepared by extrusion spheronization, was achieved with 27.00% (w/w) Ambroxol hydrochloride, 48.70% (w/w) Compritol 888 ATO, and 24.30% (w/w) EC(7 Fp) with 40 degrees C for 12 h. Comparing the single matrix materials consisting of just the wax or water-insoluble in the complex matrix system containing wax and water-insoluble polymer, the release of the drug can be far more retarded, when the formulations have undergone the process of heat treatment. Furthermore, the combination of the two polymers, with flexible matrix formation methods, will offer a very promising way of producing matrix pellets instead of coated controlled-release pellets to meet various demands of drug release. |
| Databáze: | OpenAIRE |
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