Impact of chemotherapy on prognosis of resectable pathological T3N0M0 esophageal cancer patients: a population-based study
| Autor: | Xiaojun Chen, Qian Ding, Xiang Gu, Yizhi Ge, Guangyu Tian, Jia Liu, Junfeng Chu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Logistic regression 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Propensity Score Pathological Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over Chemotherapy business.industry Proportional hazards model General Medicine Middle Aged Esophageal cancer Prognosis medicine.disease Logistic Models 030220 oncology & carcinogenesis Propensity score matching Adenocarcinoma Female business |
| Zdroj: | Future Oncology. 17:3925-3940 |
| ISSN: | 1744-8301 1479-6694 |
| Popis: | Aims: This study aimed to retrospectively determine the influence factors and survival effects of chemotherapy in pathological T3N0M0 esophageal cancer (EC) patients based on histological type. Methods: A total of 1136 pathological T3N0M0 EC patients who had surgery were chosen from the Surveillance, Epidemiology and End Results database. The patients were divided into subgroups based on histological type and chemotherapy status. Multivariate logistic regression, log-rank test and Cox regression were used to identify prognostic risk factors and survival differences. A propensity score matching analysis was applied to adjust the covariates. The impact of additional chemotherapy was also assessed in patients who had postoperative radiotherapy. Results: The 5-year overall survival was 36.4% for all patients. Chemotherapy was an independent protective factor of survival in both adenocarcinoma and squamous cell carcinoma patients. In the survival analysis, chemotherapy significantly improved the prognosis of EC patients, both for adenocarcinoma and squamous cell carcinoma. Propensity score matching analysis validated these results. Conclusion: Chemotherapy is recommended for pathological T3N0M0 EC patients regardless of histological type. |
| Databáze: | OpenAIRE |
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