Intravitreal triamcinolone for the treatment of diabetic macular edema
| Autor: | Elizabeth R. Mendez, D. V. Alfaro, Joaquin Marticorena, Michelle Rothen, Maribel Fernandez, Francisco Gómez-Ulla |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Triamcinolone acetonide Visual acuity genetic structures Endocrinology Diabetes and Metabolism medicine.medical_treatment Anti-Inflammatory Agents Vitrectomy Triamcinolone Macular Edema chemistry.chemical_compound Endocrinology Diabetes mellitus Ophthalmology Medicine Humans Macular edema Diabetic Retinopathy Laser Coagulation business.industry Progressive visual loss Diabetic retinopathy medicine.disease eye diseases Vascular endothelial growth factor Vitreous Body chemistry medicine.symptom business medicine.drug Half-Life |
| Zdroj: | Current diabetes reviews. 2(1) |
| ISSN: | 1573-3998 |
| Popis: | Diabetic macular edema is one of the leading causes of visual loss in first world countries and the first cause in diabetic retinopathy. The Early Treatment Diabetic Retinopathy Study showed a significant benefit in using focal laser photocoagulation for the treatment of macular edema, more specifically defined as clinically significant macular edema. Nevertheless, progressive visual loss is found in the 26% of patients with diabetic macular edema treated with photocoagulation. The failure of laser treatment and the destructive nature of the therapy has forced researchers to pursue new alternatives including vitrectomy with or without internal limiting membrane peels, the use of proteinkinase C inhibitors, intravitreal injections of antibodies that inhibit the vascular endothelial growth factor, somatostatin analog, or the intravitreal injection with corticosteroids. Triamcinolone acetonide is glucocoticosteroid with antiangiogenic and antiedematous properties. Publications evaluating the safety and efficacy of intravitreal injection of triamcinolone in the treatment of diabetic macular edema show varying outcomes with respect to the increases of visual acuity and decreases in foveal thickness. Despite this, intravitreal triamcinolone is a treatment that has evolved quickly and is considered increasingly useful. |
| Databáze: | OpenAIRE |
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